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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제5호
- 발행연도
- 2012.1
- 수록면
- 622 - 627 (6page)
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초록· 키워드
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Mast cells and basophils are important effector cells in immunoglobulin-E (IgE)-mediated allergic reactions.
Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcεRI-mediated allergic reaction. We determined that 6-methoxyluteolin inhibited anti-FcεRI α chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover,the inhibitory effects of 6-methoxyluteolin on the cell surface expression and the mRNA level of the FcεRI αchain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR),respectively. Therefore, these results show that 6-methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI αchain.
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참고문헌 (23)
참고문헌 신청
Beaven, M. A. / 1993 / Signal transduction by Fc receptors: The FcεRI case / Immunol. Today 14 : 222 ~ 226
Drombrowicz, D. / 1993 / Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor ε chain gene / Cell 75 : 969 ~ 976
Fujimura, Y. / 2001 / A tea catechin suppresses the expression of the high-affinity IgE receptor FcεRI in human basophilic KU812 cells / J. Agric. Food Chem 49 : 2527 ~ 253
Fujimura, Y. / 2002 / Antiallergic tea catechin, (-)- epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcεRI expression in human basophilic KU812 cells / J. Agric. Foo
Gauchat, J. F. / 1993 / Induction of human IgE synthesis in B cells by mast cells and basophils / Nature 365 : 340 ~ 343
Drombrowicz, D. / 1993 / Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor ε chain gene / Cell 75 : 969 ~ 976
Fujimura, Y. / 2001 / A tea catechin suppresses the expression of the high-affinity IgE receptor FcεRI in human basophilic KU812 cells / J. Agric. Food Chem 49 : 2527 ~ 253
Fujimura, Y. / 2002 / Antiallergic tea catechin, (-)- epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcεRI expression in human basophilic KU812 cells / J. Agric. Foo
Gauchat, J. F. / 1993 / Induction of human IgE synthesis in B cells by mast cells and basophils / Nature 365 : 340 ~ 343
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