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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제5호
- 발행연도
- 2012.1
- 수록면
- 708 - 720 (13page)
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초록· 키워드
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In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stressinduced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH)immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced openarm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.
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참고문헌 (19)
참고문헌 신청
Bhatnagar, S. / 1995 / Effects of chronic intermittent cold stress on pituitary adrenocortical and sympathetic adrenomedullary functioning / Physiol. Behav 57 : 633 ~ 639
Bignante, E. A. / 2008 / Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress / Eur. Neuropsychopharmacol 18 : 578 ~ 588
Bondi, C. O. / 2010 / Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by alpha1-adrenergic receptors in medial prefrontal co
Carvalho, M. C. / 2008 / Anxiolytic-like effects of substance P administration into the dorsal, but not ventral, hippocampus and its influence on serotonin / Peptides 29 : 11
Chotiwat, C. / 2008 / Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats / Am. J. Physiol. Regul. Int
Bignante, E. A. / 2008 / Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress / Eur. Neuropsychopharmacol 18 : 578 ~ 588
Bondi, C. O. / 2010 / Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by alpha1-adrenergic receptors in medial prefrontal co
Carvalho, M. C. / 2008 / Anxiolytic-like effects of substance P administration into the dorsal, but not ventral, hippocampus and its influence on serotonin / Peptides 29 : 11
Chotiwat, C. / 2008 / Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats / Am. J. Physiol. Regul. Int
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