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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제11호
- 발행연도
- 2015.1
- 수록면
- 1,960 - 1,965 (6page)
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Rabbit hemorrhagic disease virus (RHDV) is highly contagious and often causes fatal disease that affects both wild and domestic rabbits of the species Oryctolagus cuniculus. A highly pathogenic RHDV variant (RHDVa) has been circulation in the Korean rabbit population since 2007 and has a devastating effect on the rabbit industry in Korea. A highly pathogenic RHDVa was isolated from naturally infected rabbits, and the gene encoding the VP60 protein was cloned into a baculovirus transfer vector and expressed in insect cells. The hemagglutination titer of the Sf-9 cell lysate infected with recombinant VP60 baculovirus was 131,072 units/50 μl and of the supernatant 4,096 units/50 μl. Guinea pigs immunized twice intramuscularly with a trial inactivated RHDVa vaccine containing recombinant VP60 contained 2,152 hemagglutination inhibition (HI) geometric mean titers. The 8-week-old white rabbits inoculated with one vaccine dose were challenged with a lethal RHDVa 21 days later and showed 100% survival rates. The recombinant VP60 protein expressed in a baculovirus system induced high HI titers in guinea pigs and rendered complete protection, which led to the development of a novel inactivated RHDVa vaccine.
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참고문헌 (22)
참고문헌 신청
[학술지(정기간행물
Bertagnoli S / 1996 / Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid p
Boga JA / 1994 / Molecular cloning, sequencing and expression in Escherichia coli of the capsid protein gene from rabbit haemorrhagic disease virus (Spanish isolate AST/89) /
Capucci L / 1998 / A further step in the evolution of rabbit hemorrhagic disease virus: the appearance of the first consistent antigenic variant / Virus Res 58 : 115 ~ 126
Castanon S / 1999 / Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus / J. Virol 73 : 4452 ~ 4455
Bertagnoli S / 1996 / Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid p
Boga JA / 1994 / Molecular cloning, sequencing and expression in Escherichia coli of the capsid protein gene from rabbit haemorrhagic disease virus (Spanish isolate AST/89) /
Capucci L / 1998 / A further step in the evolution of rabbit hemorrhagic disease virus: the appearance of the first consistent antigenic variant / Virus Res 58 : 115 ~ 126
Castanon S / 1999 / Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus / J. Virol 73 : 4452 ~ 4455
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