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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제9호
- 발행연도
- 2013.1
- 수록면
- 1,322 - 1,326 (5page)
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New antifungal agents are required to compensate for the increase in resistance to standard antifungal agents of Candida albicans, which is an important opportunistic fungal pathogen that causes minor infections in many individuals but very serious infections in those who are immune-compromised. In this study, combinations of theaflavin and epicatechin are investigated as potential antifungal agents and also to establish whether antifungal synergy exists between these two readily accessible and cost-effective polyphenols isolated from black and green tea. The results of disc diffusion assays showed stronger antibacterial activity of theaflavin:epicatechin combinations against C. albicans NCTC 3255 and NCTC 3179, than that of theaflavin alone. Minimum inhibitory concentrations (MICs) of 1,024 μg/ml with theaflavin and 128-256 μg/ml with theaflavin:epicatechin combinations were found. The fractional inhibitory concentration indexes were calculated, and the synergy between theaflavin and epicatechin against both isolates of C. albicans was confirmed. Theaflavin:epicatechin combinations show real potential for future use as a treatment for infections caused by C. albicans.
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참고문헌 (20)
참고문헌 신청
Bet ts JW / 2012 / Minimum inhibitory and bactericidal concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of S
Betts JW / 2011 / Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia / Int
Cho YS / 2008 / Antibacterial effects of green tea polyphenols on clinical isolates of methicillinresistant Staphylococcus aureus / Curr. Microbiol 57 : 542 ~ 546
Evensen NA / 2009 / The effects of tea polyphenol on Candida albicans: inhibition of biofilm formation and proteasome inactiviation / Can. J. Microbiol 55 : 1033 ~ 1039
Ferreira C / 2010 / Candida albicans virulence and drug-resistance requires the O-actyltransferase Gup1p / BMC Microbiol 10 : 238 ~
Betts JW / 2011 / Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia / Int
Cho YS / 2008 / Antibacterial effects of green tea polyphenols on clinical isolates of methicillinresistant Staphylococcus aureus / Curr. Microbiol 57 : 542 ~ 546
Evensen NA / 2009 / The effects of tea polyphenol on Candida albicans: inhibition of biofilm formation and proteasome inactiviation / Can. J. Microbiol 55 : 1033 ~ 1039
Ferreira C / 2010 / Candida albicans virulence and drug-resistance requires the O-actyltransferase Gup1p / BMC Microbiol 10 : 238 ~
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