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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제11호
- 발행연도
- 2012.1
- 수록면
- 1,457 - 1,466 (10page)
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초록· 키워드
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Antimicrobial peptides (AMPs) exert antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viruses by various mechanisms. AMPs commonly possess particular characteristics by harboring cationic and amphipathic structures and binding to cell membranes,resulting in the leakage of essential cell contents by forming pores or disturbing lipid organization. These membrane disruptive mechanisms of AMPs are possible to explain according to the various structure forming pores in the membrane. Some AMPs inhibit DNA and/or RNA synthesis as well as apoptosis induction by reactive oxygen species (ROS) accumulation and mitochondrial dysfunction. Specifically, mitochondria play a major role in the apoptotic pathway. During apoptosis induced by AMPs,cells undergo cytochrome c release, caspase activation,phosphatidylserine externalization, plasma or mitochondrial membrane depolarization, DNA and nuclei damage, cell shrinkage, apoptotic body formation, and membrane blebbing. Even AMPs, which have been reported to exert membrane-active mechanisms, induce apoptosis in yeast.
These phenomena were also discovered in tumor cells treated with AMPs. The apoptosis mechanism of AMPs is available for various therapeutics such as antibiotics for antibiotic-resistant pathogens that resist to the membrane active mechanism, and antitumor agents with selectivity to tumor cells.
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참고문헌 (23)
참고문헌 신청
Aarbiou, J. / 2006 / Mechanisms of cell death induced by the neutrophil antimicrobial peptides α- defensins and LL-37 / Inflamm. Res 55 : 119 ~ 127
Aerts, A. M. / 2009 / The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans / FEBS Lett 583 : 2513 ~ 2516
Andres, M. T. / 2008 / Human lactoferrin induces apoptosis-like cell death in Candida albicans: Critical role of K+-channel-mediated K+ efflux / Antimicrob. Agents Chemother
Bak, M. / 2001 / Conformation of alamethicin in oriented phospholipid bilayers determined by (15)N solid-state nuclear magnetic resonance / Biophys. J 81 : 1684 ~ 1698
Barroso, G. / 2006 / Mitochondrial membrane potential integrity and plasma membrane translocation of phosphatidylserine as early apoptotic markers: A comparison of two differ
Aerts, A. M. / 2009 / The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans / FEBS Lett 583 : 2513 ~ 2516
Andres, M. T. / 2008 / Human lactoferrin induces apoptosis-like cell death in Candida albicans: Critical role of K+-channel-mediated K+ efflux / Antimicrob. Agents Chemother
Bak, M. / 2001 / Conformation of alamethicin in oriented phospholipid bilayers determined by (15)N solid-state nuclear magnetic resonance / Biophys. J 81 : 1684 ~ 1698
Barroso, G. / 2006 / Mitochondrial membrane potential integrity and plasma membrane translocation of phosphatidylserine as early apoptotic markers: A comparison of two differ
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