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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제12호
- 발행연도
- 2008.1
- 수록면
- 1,997 - 2,003 (7page)
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초록· 키워드
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Cordyceps militaris is well known as a traditional medicinal
mushroom and has been shown to exhibit immunostimulatory
and anticancer activities. In this study, we investigated the
apoptosis induced by an aqueous extract of C. militaris
(AECM) via the activation of caspases and altered
mitochondrial membrane permeability in human breast
cancer MDA-MB-231 cells. Exposure to AECM induced
apoptosis, as demonstrated by a quantitative analysis of
nuclear morphological change and a flow cytometric
analysis. AECM increased hyperpolarization of mitochondrial
membrane potential and promoted the activation of caspases.
Both the cytotoxic effect and apoptotic characteristics
induced by AECM treatment were significantly inhibited
by z-DEVD-fmk, a caspase-3 inhibitor, which demonstrates
the important role of caspase-3 in the observed cytotoxic
effect. AECM-induced apoptosis was associated with the
inhibition of Akt activation in a time-dependent manner,
and pretreatment with LY294002, a PI3K/Akt inhibitor,
significantly increased AECM-induced apoptosis. The results
indicated that AECM-induced apoptosis may relate to the
activation of caspase-3 and mitochondria dysfunctions
that correlate with the inactivation of Akt.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Alkhalaf, M. / 2008 / Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3- dependent pathway. Arch / Med. Res 39 : 162 ~ 16
Chung, H. / 2008 / Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts / Int. J
Datta, S. R. / 1999 / Cellular survival: A play in three Akts / Genes Dev 13 : 2905 ~ 2927
Dizin, E. / 2008 / Caspase-dependent BRCA1 cleavage facilitates chemotherapyinduced apoptosis / Apoptosis 13 : 237 ~ 246
Dlugosz, P. J. / 2006 / Bcl-2 changes conformation to inhibit Bax oligomerization / EMBO J 25 : 2287 ~ 2296
Chung, H. / 2008 / Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts / Int. J
Datta, S. R. / 1999 / Cellular survival: A play in three Akts / Genes Dev 13 : 2905 ~ 2927
Dizin, E. / 2008 / Caspase-dependent BRCA1 cleavage facilitates chemotherapyinduced apoptosis / Apoptosis 13 : 237 ~ 246
Dlugosz, P. J. / 2006 / Bcl-2 changes conformation to inhibit Bax oligomerization / EMBO J 25 : 2287 ~ 2296
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