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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제4호
- 발행연도
- 2008.1
- 수록면
- 799 - 804 (6page)
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초록· 키워드
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Retrovirus tropism can be restricted by host cell factors such as Fv1, TRIM5α, and Lv1 that inhibit infection by targeting the incoming viral capsid. The Fv1 gene inhibits murine leukemia virus infection in mice, but the precise mechanism of Fv1-mediated restriction is poorly understood.
Our previous studies had demonstrated that Fv1-mediated viral tropism can be determined within the capsid protein at position 114. To study the interaction between Fv1 and CA, we introduced amino acid substitution and deletion at this site in the N-tropic AKV capsid gene. The mutated two-LTR proviral DNAs were introduced into SC-1 cells by transfection. After transfection, cell supernatants collected from transfected cells were tested for host range susceptibility. The result indicated that substitution of amino acids did not alter tropism, but the deletion of 114His produced a virus with unusual tropism. The novel phenotype produced here failed to replicate in Fv1- expressing cells. This mutant virus showing such an extreme restriction pattern would be useful for studying the mechanism of Fv1-mediated restriction.
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참고문헌 (25)
참고문헌 신청
Aagaard, L. / 2002 / Fv1-like restriction of N-tropic replicationcompetent murine leukaemia viruses in mCAT-1-expressing human cells. J. Gen / Virol 83 : 439 ~ 442
Baumann, J. G. / 2006 / Intracellular restriction factors in mammalian cells -- An ancient defense system finds a modern foe. Curr / HIV Res 4 : 141 ~ 168
Besnier, C. / 2002 / Restriction of lentivirus in monkeys. Proc. Natl. Acad / Sci 99 : 11920 ~ 11925
Besnier, C. / 2003 / Characterization of murine leukemia virus restriction in mammals / Virol 77 : 13403 ~ 13406
Best, S. / 1996 / Positional cloning of the mouse retrovirus restriction gene Fv1 / Nature 382 : 826 ~ 829
Baumann, J. G. / 2006 / Intracellular restriction factors in mammalian cells -- An ancient defense system finds a modern foe. Curr / HIV Res 4 : 141 ~ 168
Besnier, C. / 2002 / Restriction of lentivirus in monkeys. Proc. Natl. Acad / Sci 99 : 11920 ~ 11925
Besnier, C. / 2003 / Characterization of murine leukemia virus restriction in mammals / Virol 77 : 13403 ~ 13406
Best, S. / 1996 / Positional cloning of the mouse retrovirus restriction gene Fv1 / Nature 382 : 826 ~ 829
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