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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제4호
- 발행연도
- 2005.1
- 수록면
- 694 - 700 (7page)
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초록· 키워드
오류제보하기
Defects in the mitotic spindle or in the attachmentof chromosomes to the spindle are believed to release anactivated form of spindle checkpoint complex that inhibitsAPC-dependent ubiquitination and subsequently arrests thecell cycle at metaphase. When the spindle assembly isdisrupted, the fission yeast mitotic arrest deficient (mad)mutants fail to arrest and rapidly lose viability. To enhance ourunderstanding of the molecular mechanisms for the pathwayof checkpoint function, the functional characterizations ofMad1p from Schizosaccharomyces pombe involved in thisprocess have been carried out. Yeast two-hybrid and variousdeletion analyses of S. pombe Mad1p reveal that the Cterminus of Mad1p is critical for the binding of Mad2p andmaintenance of Mad1p-Mad2p interaction. In addition, it wasfound that the Mad1p region (residues 206-356) is essentialfor Mad1p-other checkpoint components. Mad1p truncatingthis region is sufficient to bind Mad2p but abolishes thecheckpoint function, indicating that the checkpoint functionis necessary for interaction of Mad1p-other checkpointcomponents. The possible functions of S. pombe Mad1p atthe cell cycle checkpoint are discussed.
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참고문헌 (28)
참고문헌 신청
/ 1996 / The fission yeast dma1gene is a component of the spindle assembly checkpoint required to prevent septum formation and premature exitfrom mitosis if spindle function
A / 1991 / Predictingcoiled coils from protein sequences : 1162 ~ 252 1164
A / 1998 / Fizzyis required for activation of the APC/cyclosome in Xenopusegg extracts 17 : 3565 ~ 3575
A / 2002 / Control of localization of a spindle checkpoint protein 115 : 1603 ~ 1610
Brady / 2000 / Bub1p and Bub3p is crucial for spindlecheckpoint function 10 : 675 ~ 678
A / 1991 / Predictingcoiled coils from protein sequences : 1162 ~ 252 1164
A / 1998 / Fizzyis required for activation of the APC/cyclosome in Xenopusegg extracts 17 : 3565 ~ 3575
A / 2002 / Control of localization of a spindle checkpoint protein 115 : 1603 ~ 1610
Brady / 2000 / Bub1p and Bub3p is crucial for spindlecheckpoint function 10 : 675 ~ 678
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