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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 73 - 81 (9page)
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Salsola collina, also known as Russian thistle, is widely distributed in and around waste facilities, roadsides, and drought and semi-drought areas, and is used as a traditional folk remedy in Chinese medicine for the treatment of hypertension. In this study, we have evaluated the anti-oxidative and anti-cancer activities of the ethanol extract of S. collina Pall. (EESC), and the molecular mechanisms of its anti-cancer effects on human colon carcinoma HT29 cells. EESC exhibited anti-oxidative activity through DPPH radical scavenging capacity and showed cytotoxic activity in a dose-dependent manner in HT29 cells. After EESC treatment, HT29 cells altered their morphology, becoming smaller and irregular in shape. EESC also induced cell accumulation in the G2/M phase in a dose-dependent manner, accompanied by a decrease of cell population in the G1 phase. The G2/M arrest by EESC was associated with the increased expression of cyclin-dependent kinase (CDK) inhibitor p21 and Wee1 kinase, which phosphorylates, or inactivates, Cdc2. EESC treatment induced the phosphorylation of Cdc2 and Cdc25C, and inhibited cyclin A and Cdc25C protein expression. In addition, S arrest was induced by the highest concentration of EESC treatment, associated with a decrease of cyclin A and Cdk2 expression. These findings suggest that EESC may possess remarkable anti-oxidative activity and exert an anti-cancer effect in HT29 cells by cell cycle regulation.
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참고문헌 (25)
참고문헌 신청
Aktas H / 1997 / Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1and the Cdk inhibitor p27KIP1 / Mol. Cell. Biol 17 : 3850 ~ 3857
Albert H / 2011 / Differential expression of CDC25 phosphatases splice variants in human breast cancer cells / Clin. Chem. Lab. Med 49 : 1707 ~ 1714
An Y / 1999 / Prospective and retrospective studies on risk factors of four most common cancers in Korean males: stomach, live, lung and colorectum / Ministry of Health & Welfare
Aranha O / 2000 / Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line / Cli
Arellano M / 1997 / Regulation of CDK/cyclin complexes during the cell cycle / Int. J. Biochem. Cell Biol 29 : 559 ~ 573
Albert H / 2011 / Differential expression of CDC25 phosphatases splice variants in human breast cancer cells / Clin. Chem. Lab. Med 49 : 1707 ~ 1714
An Y / 1999 / Prospective and retrospective studies on risk factors of four most common cancers in Korean males: stomach, live, lung and colorectum / Ministry of Health & Welfare
Aranha O / 2000 / Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line / Cli
Arellano M / 1997 / Regulation of CDK/cyclin complexes during the cell cycle / Int. J. Biochem. Cell Biol 29 : 559 ~ 573
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