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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제4호
- 발행연도
- 2012.1
- 수록면
- 484 - 493 (10page)
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초록· 키워드
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BolA protein homologs are widely distributed in nature.
In this report, we have studied for the first time YrbA, the only BolA homolog present in Escherichia coli, which we have renamed ibaG. We have constructed single and multiple ibaG mutants, and overexpressed ibaG in wildtype strains, in order to characterize this gene. The ibaG phenotypes are different from the bolA-associated round morphologies or growth profiles. Interestingly, ibaG and bolA single- and double-deletion mutants grow faster and have higher viabilities in rich media, whereas the overexpressed strains are significantly growth impaired.
However, the mutant strains have lower viabilities than the wild type in the late stationary phase, indicating that both bolA and ibaG are important for survival in difficult growth conditions. bolA, as a transcription factor, binds to some promoters, but ibaG does not interact with the same DNA regions. We have determined that ibaG is transcribed in an operon with the murA gene, involved in the synthesis of peptidoglycan precursors. ibaG was also seen to change its mRNA expression pattern in response to acidic stress.
ibaG may thus represent a new gene involved in cell resistance against acid stress.
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참고문헌 (23)
참고문헌 신청
Aldea, M. / 1988 / Identification, cloning, and expression of bolA, an ftsZ-dependent morphogene of Escherichia coli / J. Bacteriol 170 : 5169 ~ 5176
Aldea, M. / 1989 / Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene / EMBO J 8 : 3923 ~ 3931
Aldea, M. / 1990 / Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters / EMBO J 9 : 3787 ~ 3794
Baba, T. / 2006 / Construction of Escherichia coli K-12 inframe, single-gene knockout mutants: The Keio collection / Mol. Syst. Biol 2 : 2006 ~
Bachmann, B. J. / 1980 / Linkage map of Escherichia coli K-12, edition 6 / Microbiol. Rev 44 : 1 ~ 56
Aldea, M. / 1989 / Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene / EMBO J 8 : 3923 ~ 3931
Aldea, M. / 1990 / Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters / EMBO J 9 : 3787 ~ 3794
Baba, T. / 2006 / Construction of Escherichia coli K-12 inframe, single-gene knockout mutants: The Keio collection / Mol. Syst. Biol 2 : 2006 ~
Bachmann, B. J. / 1980 / Linkage map of Escherichia coli K-12, edition 6 / Microbiol. Rev 44 : 1 ~ 56
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