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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제1호
- 발행연도
- 2012.1
- 수록면
- 80 - 83 (4page)
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초록· 키워드
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The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5-bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4showed a potent antibacterial activity against the methicillinresistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 μg/ml,respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values of 11.0, 17.0, 12.0,and 7.0 μM, respectively, which were more active than the positive control, L-ascorbic acid (IC50, 20.0 μM).
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참고문헌 (15)
참고문헌 신청
Blunt, J. W. / 2011 / Marine natural products / Nat. Prod. Rep 28 : 196 ~ 268
Clark, B. R. / 2007 / The effect of halide salts on the production of Gymnoascus reessii polyenylpyrroles / J. Nat. Prod 70 : 665 ~ 667
Feling, R. H. / 2003 / Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora / Angew. Chem
Jensen, P. R. / 2000 / Marine microorganisms and drug discovery: Current status and future potential, In Drugs from the Sea / Karger : 6 ~ 29
Lam, K. S. / 2007 / Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica / J. Antibiot 60 : 13 ~ 19
Clark, B. R. / 2007 / The effect of halide salts on the production of Gymnoascus reessii polyenylpyrroles / J. Nat. Prod 70 : 665 ~ 667
Feling, R. H. / 2003 / Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora / Angew. Chem
Jensen, P. R. / 2000 / Marine microorganisms and drug discovery: Current status and future potential, In Drugs from the Sea / Karger : 6 ~ 29
Lam, K. S. / 2007 / Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica / J. Antibiot 60 : 13 ~ 19
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