지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제4호
- 발행연도
- 2011.1
- 수록면
- 430 - 437 (8page)
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초록· 키워드
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The effects of the agitation and aeration rates on the production of serratiopeptidase (SRP) in a 5-L fermentor (working volume 2-l) were systematically investigated using Serratia marcescens NRRL B-23112. The dissolved oxygen concentration, pH, biomass, SRP yield, and maltose utilization were all continuously measured during the course of the fermentation runs. The efficiencies of the aeration and agitation were evaluated based on the volumetric mass transfer coefficient (KLa). The maximum SRP production of 11,580 EU/ml with a specific SRP productivity of 78.8 EU/g/h was obtained with an agitation of 400 rpm and aeration of 0.075 vvm, which was 58%higher than the shake-flask level. The KLa for the fermentation system supporting the maximum production (400 rpm, 0.075 vvm) was 11.3 h^(-1). Under these fermentor optimized conditions, kinetic modeling was performed to understand the detailed course of the fermentation process.
The resulting logistic and Luedeking-Piret models provided an effective description of the SRP fermentation, where the correlation coefficients for cell growth, SRP formation,and substrate consumption were 0.99, 0.94, and 0.84,respectively, revealing a good agreement between the model-predicted and experimental results. The kinetic analysis of the batch fermentation process for the production of SRP demonstrated the SRP production to be mixed growth associated.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간
Ahamed, A / 2010 / Effect of mechanical agitation on the production of cellulases by Trichoderma reesei RUT-C30 in a draft-tube airlift bioreactor / Biochem. Eng. J 49 : 379
Blakebrough, N / 1981 / Scale-up of whey fermentation in a pilot-scale fermenter / Eur. J. Appl. Microbiol. Biotechnol 12 : 173 ~ 178
Braun, V / 1980 / Excretion of a protease by Serratia marcescens / Arch. Microbiol 124 : 55 ~ 61
Bromke, B. J / 1979 / Regulation of extracellular protease formation by Serratia marcescens / Can. J. Microbiol 25 : 47 ~ 52
Ahamed, A / 2010 / Effect of mechanical agitation on the production of cellulases by Trichoderma reesei RUT-C30 in a draft-tube airlift bioreactor / Biochem. Eng. J 49 : 379
Blakebrough, N / 1981 / Scale-up of whey fermentation in a pilot-scale fermenter / Eur. J. Appl. Microbiol. Biotechnol 12 : 173 ~ 178
Braun, V / 1980 / Excretion of a protease by Serratia marcescens / Arch. Microbiol 124 : 55 ~ 61
Bromke, B. J / 1979 / Regulation of extracellular protease formation by Serratia marcescens / Can. J. Microbiol 25 : 47 ~ 52
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