지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 275 - 284 (10page)
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초록· 키워드
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This study was orchestrated with the purpose of uncovering new nutraceutical resources possessing biological activities in the plant kingdom. To fulfill our objective, we analyzed several Chinese plants and selected three possessing powerful anti-oxidative activities. The anti-oxidative and anti-inflammatory effects these three Chinese plants, Malus hupehensis, Ophiorrhiza cantonensis, and Psychotria rubra ethanol extracts were then evaluated. First of all, they possessed potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl, similar with that of ascorbic acid, used as a positive control. Moreover, they inhibited lipopolysaccharide (LPS)- and hydrogen peroxide-induced reactive oxygen species, in a dose-dependent manner, in RAW 264.7 cells. Also, they induced the expression of an anti-oxidative enzyme, heme oxygenase 1, and its upstream transcription factor, nuclear factor-E2-related factor 2. Furthermore, they suppressed LPS-induced nitric oxide (NO) formation, without cytotoxicity. The inhibition of NO formation was the result of the down regulation of inducible NO synthase (iNOS). The suppression of NO and iNOS by the three extracts might be the result of modulation by the upstream transcription factors, nuclear factor κB and activator protein-1. Taken together, these results indicate that these three Chinese plants possess potent anti-oxidative and anti-inflammatory activities. Therefore, they might be utilized as promising materials in the field of nutraceuticals.
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참고문헌 (24)
참고문헌 신청
Awad N / 2011 / N-acetyl-cysteine (NAC) attenuates LPS-induced maternal and amniotic fluid oxidative stress and inflammatory responses in the preterm gestation / Am. J. Obste
Bryan HK / 2013 / The Nrf2cell defence pathway: Keap1-dependent and -independent mechanisms of regulation / Biochem. Pharmacol 85 : 705 ~ 717
Chapple SJ / 2012 / Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging / Int. J. Biochem. Cell Biol 44 : 1315 ~ 1
Chawla A / 2011 / Macrophage-mediated inflammation in metabolic disease / Nat. Rev. Immunol 11 : 738 ~ 749
Giudice A / 2010 / Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents / Meth. Mol. Biol 647 : 37 ~ 74
Bryan HK / 2013 / The Nrf2cell defence pathway: Keap1-dependent and -independent mechanisms of regulation / Biochem. Pharmacol 85 : 705 ~ 717
Chapple SJ / 2012 / Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging / Int. J. Biochem. Cell Biol 44 : 1315 ~ 1
Chawla A / 2011 / Macrophage-mediated inflammation in metabolic disease / Nat. Rev. Immunol 11 : 738 ~ 749
Giudice A / 2010 / Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents / Meth. Mol. Biol 647 : 37 ~ 74
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