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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 13 - 18 (6page)
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Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals.
Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity.
In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.
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참고문헌 (18)
참고문헌 신청
Bahn, Y. S / 2004 / Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade /
Bahn, Y. S / 2005 / Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence / Curr. Biol. 15 : 2013 ~ 2020
Bahn, Y. S / 2005 / Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans / Mol. Biol. Cell. 16 : 2285 ~ 2300
Chen, S / 2000 / Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in ustralia and New Zealand / Australasian Cryptococ
Henry,R.P. / 1996 / Multiple roles of carbonic anhydrase in cellular transport and metabolism / Annu. Rev. Physiol. 58 : 523 ~ 538
Bahn, Y. S / 2005 / Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence / Curr. Biol. 15 : 2013 ~ 2020
Bahn, Y. S / 2005 / Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans / Mol. Biol. Cell. 16 : 2285 ~ 2300
Chen, S / 2000 / Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in ustralia and New Zealand / Australasian Cryptococ
Henry,R.P. / 1996 / Multiple roles of carbonic anhydrase in cellular transport and metabolism / Annu. Rev. Physiol. 58 : 523 ~ 538
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Unravelling of the Target of Rapamycin (TOR1) Kinase Signaling Pathway in Human Fungal Pathogen Cryptococcus neoformans
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Systematic Analysis of Signaling Pathways Associated with Melanin Production of Cryptococcus neoformans
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The Role of Iron-Sulfur Cluster Proteins Involved in Amino Acid Biosynthesis in the Human Fungal Pathogen Cryptococcus neoformans
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Kinome Webs Reveal Novel Pathogenicity Networks in Human Fungal Pathogen Cryptococcus neoformans
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Characterization of the Oxidative Stress Response Governed by Sulfiredoxin, Srx1, via the HOG Signaling Pathway in Human Fungal Pathogen Cryptococcus neoformans
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Gpp2 is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans
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Unraveling the Role of Pseudouridylation in a Fungal Pathogen Cryptococcus neoformans
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Unraveling the Role of Pseudouridylation in Opportunistic Fungal Pathogen Cryptococcus neoformans
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Genome Plasticity in Cryptococcus neoformans : How It Contributes to Survival under Drug Stress
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enome-wide Transcriptional Networks of Iron Regulators in the Human Fungal Pathogen Cryptococcus neoformans
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