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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제5호
- 발행연도
- 2018.1
- 수록면
- 816 - 820 (5page)
이용수
초록· 키워드
오류제보하기
The stringent response (SR), which is activated by accumulation of (p)ppGpp under conditions of growth-inhibiting stresses, plays an important role on growth and virulence in Vibrio cholerae. Herein, we carried out a genome-wide screen using transposon random mutagenesis to identify genes controlled by SR in a (p)ppGpp-overproducing mutant strain. One of the identified SR target genes was flaC encoding flagellin. Genetic studies using flaC and SR mutants demonstrated that FlaC was involved in bacterial growth, toxin production, and normal flagellum function under conditions of high (p)ppGpp levels, suggesting FlaC plays an important role in SR-induced pathogenicity in V. cholerae.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Dalebroux ZD / 2012 / ppGpp: magic beyond RNA polymerase / Nat. Rev. Microbiol. 10:203~212
Srivatsan A / 2008 / Control of bacterial transcription, translation and replication by (p)ppGpp / Curr. Opin. Microbiol. 11:100~105
Das B / 2009 / Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene / Mol. Microbiol. 72:380~398
Lee KM / 2012 / Activation of cholera toxin production by anaerobic respiration of trimethylamine N-oxide in Vibrio cholerae / J. Biol. Chem. 287:39742~39752
Oh YT / 2014 / Cholera toxin production during anaerobic trimethylamine N-oxide respiration is mediated by stringent response in Vibrio cholerae / J. Biol. Chem. 289:13232~13242
Srivatsan A / 2008 / Control of bacterial transcription, translation and replication by (p)ppGpp / Curr. Opin. Microbiol. 11:100~105
Das B / 2009 / Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene / Mol. Microbiol. 72:380~398
Lee KM / 2012 / Activation of cholera toxin production by anaerobic respiration of trimethylamine N-oxide in Vibrio cholerae / J. Biol. Chem. 287:39742~39752
Oh YT / 2014 / Cholera toxin production during anaerobic trimethylamine N-oxide respiration is mediated by stringent response in Vibrio cholerae / J. Biol. Chem. 289:13232~13242
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