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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제5호
- 발행연도
- 2018.1
- 수록면
- 809 - 815 (7page)
이용수
초록· 키워드
오류제보하기
Influenza, which is a highly contagious disease caused by the influenza A virus, continues to be a major health concern worldwide. Although the accurate and early diagnosis of influenza virus infection is important for controlling the spread of this disease and rapidly initiating antiviral therapy, the current influenza diagnostic kits are limited by their low sensitivity. In this study, we developed several new influenza nucleoprotein (NP)-specific monoclonal antibodies (mAbs) and compared their sensitivity and specificity of those with commercially available anti-NP mAbs. Three mAbs, designated M24.11, M34.3, and M34.33, exhibited higher reactivities to recombinant NPs and A/Puerto Rico/8/1934 (H1N1) viral lysates compared with the commercial mAbs, as assessed using enzyme-linked immunosorbent assays. M34.3 and M34.33 showed higher reactivities with A/California/04/09 (pandemic H1N1) and A/ Philippines/2/82 (H3N2) viral lysates than the commercial mAbs. In contrast, M24.11 had marked reactivity with H3N2 but not with pandemic H1N1. Immunofluorescent confocal microscopy showed that the three mAbs effectively detected the presence of influenza virus in lung tissues of mice infected with A/Puerto Rico/8/1934. These results indicate that the newly developed M34.3 and M34.33 mAbs could be useful for the development of influenza diagnostics.
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참고문헌 (24)
참고문헌 신청
Webster RG / 1992 / Evolution and ecology of influenza A viruses / Microbiol. Rev. 56:152~179
Cox NJ / 1999 / Influenza / Lancet 354:1277~1282
Neumann G / 2009 / Emergence and pandemic potential of swine-origin H1N1 influenza virus / Nature 459:931~939
Molinari NA / 2007 / The annual impact of seasonal influenza in the US: measuring disease burden and costs / Vaccine 25:5086~5096
Vemula SV / 2016 / Current approaches for diagnosis of influenza virus infections in humans / Viruses 8:96
Cox NJ / 1999 / Influenza / Lancet 354:1277~1282
Neumann G / 2009 / Emergence and pandemic potential of swine-origin H1N1 influenza virus / Nature 459:931~939
Molinari NA / 2007 / The annual impact of seasonal influenza in the US: measuring disease burden and costs / Vaccine 25:5086~5096
Vemula SV / 2016 / Current approaches for diagnosis of influenza virus infections in humans / Viruses 8:96
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