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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,491 - 1,499 (9page)
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초록· 키워드
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Trimethylamine N-oxide (TMAO), which is transformed from trimethylamine (TMA) through hepatic flavin-containing monooxygenases, can promote atherosclerosis. TMA is produced from dietary carnitine, phosphatidylcholine, and choline via the gut microbes. Previous works have shown that some small molecules, such as allicin, resveratrol, and 3,3-dimethyl-1- butanol, are used to reduce circulating TMAO levels. However, the use of bacteria as an effective therapy to reduce TMAO levels has not been reported. In the present study, 82 isolates were screened from healthy Chinese fecal samples on a basal salt medium supplemented with TMA as the sole carbon source. The isolates belonged to the family Enterobacteriaceae, particularly to genera Klebsiella, Escherichia, Cronobacter, and Enterobacter.
Serum TMAO and cecal TMA levels were significantly decreased in choline-fed mice treated with Enterobacter aerogenes ZDY01 compared with those in choline-fed mice treated with phosphate-buffered saline. The proportions of Bacteroidales family S24-7 were significantly increased, whereas the proportions of Helicobacteraceae and Prevotellaceae were significantly decreased through the administration of E. aerogenes ZDY01. Results indicated that the use of probiotics to act directly on the TMA in the gut might be an alternative approach to reduce serum TMAO levels and to prevent the development of atherosclerosis and “fish odor syndrome” through the effect of TMA on the gut microbiota.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bennett BJ / 2013 / Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation / Cell Metab 17 : 49 ~ 60
Bokulich NA / 2013 / Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing / Nat. Methods 10 : 57 ~ 59
Brugere JF / 2014 / Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease / Gut Microbes 5 : 5 ~ 10
Chen ML / 2016 / Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut
Edgar RC / 2013 / UPARSE: highly accurate O TU s equences from microbial amplicon reads / Nat. Methods 10 : 996 ~ 998
Bokulich NA / 2013 / Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing / Nat. Methods 10 : 57 ~ 59
Brugere JF / 2014 / Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease / Gut Microbes 5 : 5 ~ 10
Chen ML / 2016 / Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut
Edgar RC / 2013 / UPARSE: highly accurate O TU s equences from microbial amplicon reads / Nat. Methods 10 : 996 ~ 998
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