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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제24권 제8호
- 발행연도
- 2014.1
- 수록면
- 1,051 - 1,058 (8page)
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초록· 키워드
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Platelet-activating factor receptor (PAFR) plays an important role in bacterial infection and inflammation. We examined the effect of the bacterial cell wall components lipopolysaccharide (LPS) and lipoteichoic acid (LTA) from Lactobacillus plantarum (pLTA) and Staphylococcus aureus (aLTA) on PAFR expression in THP-1, a monocyte-like cell line. LPS and aLTA, but not pLTA, significantly increased PAFR expression, whereas priming with pLTA inhibited LPSmediated or aLTA-mediated PAFR expression. Expression of Toll-like receptor (TLR) 2 and 4, and CD14 increased with LPS and aLTA treatments, but was inhibited by pLTA pretreatment. Neutralizing antibodies against TLR2, TLR4, and CD14 showed that these receptors were important in LPS-mediated or aLTA-mediated PAFR expression. PAFR expression is mainly regulated by the nuclear factor kappa B signaling pathway. Blocking PAF binding to PAFR using a PAFR inhibitor indicated that LPS-mediated or aLTA-mediated PAF expression affected TNF-α production. In the mouse small intestine, pLTA inhibited PAFR, TLR2, and TLR4 expression that was induced by heat-labile toxin. Our data suggested that pLTA has an anti-inflammatory effect by inhibiting the expression of PAFR that was induced by pathogenic ligands.
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참고문헌 (22)
참고문헌 신청
Behr T / 1992 / The structure of pneumococcal lipoteichoic acid: improved preparation, chemical and mass spectrometric studies / Eur. J. Biochem 207 : 1063 ~ 1075
Bhakdi S / 1991 / Stimulation of monokine production by lipoteichoic acids / Infect. Immunol 59 : 4614 ~ 4620
Castor MG / 2012 / Platelet-activating factor receptor plays a role in the pathogenesis of graft-versushost disease by regulating leukocyte recruitment, tissue injury, and le
Dagenais P / 1997 / Modulation of platelet-activating factor receptor (PAFR)gene expression via NF kappa B in MonoMac-1 cells / Inflamm. Res 46 (2) : 161 ~ 162
Deininger S / 2003 / Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives / J. Immunol 170 : 4134 ~ 4138
Bhakdi S / 1991 / Stimulation of monokine production by lipoteichoic acids / Infect. Immunol 59 : 4614 ~ 4620
Castor MG / 2012 / Platelet-activating factor receptor plays a role in the pathogenesis of graft-versushost disease by regulating leukocyte recruitment, tissue injury, and le
Dagenais P / 1997 / Modulation of platelet-activating factor receptor (PAFR)gene expression via NF kappa B in MonoMac-1 cells / Inflamm. Res 46 (2) : 161 ~ 162
Deininger S / 2003 / Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives / J. Immunol 170 : 4134 ~ 4138
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