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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제10호
- 발행연도
- 2013.1
- 수록면
- 1,454 - 1,459 (6page)
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The changes in prodiginines productions caused by pH shock culture of Streptomyces coelicolor strains were estimated. In Streptomyces coelicolor M511, undecylprodiginine and streptorubin B productions increased 1.8-fold (37.22 mg/g) and 2.5-fold (18.61 mg/g), respectively, by pH shock (from 7.2 to 4.0). In contrast, this resulted in the significantly decreased prodigignines production in the redP deletion mutant SJM1; 3.7-fold for undecylprodiginine, 4.4-fold for streptorubin B,5.2-fold for methylundecylprodiginine, and 6.4-fold for methyldodecylundecylprodiginine,respectively. RT-PCR analyses showed that, during pH shock, expression of redD, the transcription activator gene, was increased while the expression of fabH, the decarboxylative condensation enzyme gene in fatty acid biosynthesis, was decreased in both strains. The enhanced redD expression was in good accordance with the increased total prodiginines production of M511. However, for SJM1 mutant, the decrease of fabH expression occurred more strikingly, such that it became almost completely turned off during acidic pH shock culture. Therefore, a down-regulation of fabH was considered to be the cause of decreased amount of total prodiginines produced, although redD expression was high in SJM1 mutant.
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참고문헌 (18)
참고문헌 신청
Azuma T / 2000 / Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant / Immunopharmacology 46 : 29 ~ 37
Cerdeno AM / 2001 / Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular mul
Dairi K / 2006 / Two-step synthesis of the bipyrrole precursor of prodigiosins / Tetrahedron Lett 47 : 2605 ~ 2606
D’Alessio R / 2000 / Synthesis and immunosuppresive activity of novel prodigiosin derivatives / J. Med. Chem 43 : 2557 ~ 2565
Furstner A / 2003 / Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 years / Angew. Chem. Int. Ed. Engl 42 : 3582 ~ 3603
Cerdeno AM / 2001 / Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular mul
Dairi K / 2006 / Two-step synthesis of the bipyrrole precursor of prodigiosins / Tetrahedron Lett 47 : 2605 ~ 2606
D’Alessio R / 2000 / Synthesis and immunosuppresive activity of novel prodigiosin derivatives / J. Med. Chem 43 : 2557 ~ 2565
Furstner A / 2003 / Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 years / Angew. Chem. Int. Ed. Engl 42 : 3582 ~ 3603
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