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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제5호
- 발행연도
- 2009.1
- 수록면
- 468 - 473 (6page)
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The antibiotic meroparamycin was produced in the free
culture system of Streptomyces sp. strain MAR01. Five
solid substrates (rice, wheat bran, Quaker, bread, and
ground corn) were screened for their ability to support
meroparamycin production in solid-state fermentation.
In batch culture, wheat bran recorded the highest
antibacterial activity with the lowest residual substrate
values. The highest residual substrate values were recorded
for both ground corn and Quaker. On the other hand, no
antibacterial activity was detected for rice as a solid
substrate. The use of the original strength of starch-nitrate
medium in the solid-state fermentation gave a lower
antibacterial activity compared with the free culture
system. Doubling the strength of this medium resulted in
the increase in the activity to be equivalent to the free
culture. The initial pH (7.0) of the culture medium and
2 ml of spore suspension (1 ml contains 5×109 spores/ml)
were the optima for antibiotic production. The water was
the best eluent for the extraction of the antibiotic from the
solid-state culture. Ten min was enough time to extract the
antibiotic using a mixer, whereas, 60 min was required
when shaking was applied. Semicontinuous production of
meroparamycin using a percolation method demonstrated
a more or less constant antibacterial activity over 4 runs
(450-480 µg/ml). The semicontinuous production of the
antibiotic was monitored in a fixed-bed bioreactor and the
maximum activity was attained after the fourth run
(510 µg/ml) and the overall process continued for 85 days.
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참고문헌 (24)
참고문헌 신청
4. Berdy, J. / 2005 / Bioactive microbial metabolites. A personal view / J. Antibiot 58 : 1 ~ 26
Barrios-Gonzalez, J. / 1988 / Penicillin production by solid-state fermentation. in: Solid-State Fermentation in Bioconversion of Agro-Industrial Raw Materials / Orstom : 3951 ~
Barrios-Gonzalez, J. / 1996 / Production of secondary metabolites by solid-state fermentation / Biotechnol. Annu. Rev 2 : 85 ~ 121
Bayles, K. W. / 2003 / Are the molecular strategies that control apoptosis conserved in bacteria? / Trends Microbiol 11 : 306 ~ 311
Bibb, M. J. / 2005 / Regulation of secondary metabolism in streptomycetes / Curr. Opin. Microbiol 8 : 208 ~ 215
Barrios-Gonzalez, J. / 1988 / Penicillin production by solid-state fermentation. in: Solid-State Fermentation in Bioconversion of Agro-Industrial Raw Materials / Orstom : 3951 ~
Barrios-Gonzalez, J. / 1996 / Production of secondary metabolites by solid-state fermentation / Biotechnol. Annu. Rev 2 : 85 ~ 121
Bayles, K. W. / 2003 / Are the molecular strategies that control apoptosis conserved in bacteria? / Trends Microbiol 11 : 306 ~ 311
Bibb, M. J. / 2005 / Regulation of secondary metabolism in streptomycetes / Curr. Opin. Microbiol 8 : 208 ~ 215
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