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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제3호
- 발행연도
- 2008.1
- 수록면
- 397 - 403 (7page)
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Nikkomycins are a group of peptidyl nucleoside antibiotics
with potent fungicidal, insecticidal, and acaricidal activities.
sanN was cloned from the partial genomic library of
Streptomyces ansochromogenes 7100. Gene disruption and
complementation analysis demonstrated that sanN is essential
for nikkomycin biosynthesis in S. ansochromogenes. Primer
extension assay indicated that sanN is transcribed from
two promoters (sanN-P1 and sanN-P2), and sanN-P2
plays a more important role in nikkomycin biosynthesis.
Purified recombinant SanN acts as a dehydrogenase to
convert benzoate-CoA to benzaldehyde in a randomorder
mechanism in vitro, with respective Kcat/Km values
of 3.8 mM-1s-1 and 12.0 mM-1s-1 toward benzoate-CoA
and NADH, suggesting that SanN catalyzes the formation
of picolinaldehyde during biosynthesis of nikkomycin X
and Z components in the wild-type stain. These data
would facilitate us to understand the biosynthetic pathway
of nikkomycins and to consider the combinatorial synthesis
of novel antibiotic derivatives.
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참고문헌 (22)
참고문헌 신청
Aemprapa, S. / 1998 / Implications of the xylQ gene of TOL plasmid pWW102 for the evolution of aromatic catabolic pathways / Microbiology 144 : 1387 ~ 1396
Altschul, S. F. / 1997 / Gapped BLAST and PSI-BLAST: A new generation of protein database search programs / Nucleic Acids Res 25 : 3389 ~ 3402
Arai, H. / 1998 / Adaptation of Comamonas testosteroni TA441 to utilize phenol: Organization and regulation of the genes involved in phenol degradation / Microbiology 144 : 2
Arai, H. / 2000 / Arrangement and regulation of the genes for meta-pathway enzymes required for degradation of phenol in Comamonas testosteroni TA441 / Microbiology 146 : 170
Bierman, M. / 1992 / Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp / Gene 116 : 43 ~ 49
Altschul, S. F. / 1997 / Gapped BLAST and PSI-BLAST: A new generation of protein database search programs / Nucleic Acids Res 25 : 3389 ~ 3402
Arai, H. / 1998 / Adaptation of Comamonas testosteroni TA441 to utilize phenol: Organization and regulation of the genes involved in phenol degradation / Microbiology 144 : 2
Arai, H. / 2000 / Arrangement and regulation of the genes for meta-pathway enzymes required for degradation of phenol in Comamonas testosteroni TA441 / Microbiology 146 : 170
Bierman, M. / 1992 / Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp / Gene 116 : 43 ~ 49
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