지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제3호
- 발행연도
- 2008.1
- 수록면
- 585 - 590 (6page)
이용수
초록· 키워드
오류제보하기
Human tropic Porcine Endogenous Retroviruses (PERVs) are the major concern in zoonosis for xenotransplantation because PERVs cannot be eliminated by specific pathogenfree breeding. Recently, a PERV A/C recombinant with PERV-C bearing PERV-A gp70 showed a higher infectivity (approximately 500-fold) to human cells than PERV-A.
Additionally, the chance of recombination between PERVs and HERVs is frequently stated as another risk of xenografting. Overcoming zoonotic barriers in xenotransplantation is more complicated by recombination.
To achieve successful xenotransplantation, studies on the recombination in PERVs are important. Here, we cloned and sequenced proviral PERV env sequences from pig gDNAs to analyze natural recombination. The envelope is the most important element in retroviruses as a pivotal determinant of host tropisms. As a result, a total of 164 PERV envelope genes were cloned from pigs (four conventional pigs and two miniature pigs). Distribution analysis and recombination analysis of PERVs were performed. Among them, five A/B recombinant clones were identified. Based on our analysis, we determined the minimum natural recombination frequency among PERVs to be 3%. Although a functional recombinant envelope clone was not found, our data evidently show that the recombination event among PERVs may occur naturally in pigs with a rather high possibility.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Balliet, J. W. / 1999 / Production and characterization of a soluble, active form of Tva, the subgroup A avian sarcoma and leukosis virus receptor. J / Virol 73 : 3054 ~ 3061
Ericsson, T. A. / 2003 / Identification of receptors for pig endogenous retrovirus. Proc. Natl. Acad / Sci 100 : 6759 ~ 6764
Harrison, I. / 2004 / Determinants of high titer in recombinant porcine endogenous retroviruses / Virol 78 : 13871 ~ 13879
JO, SU KYOUNG / 2007 / Genetic and Antigenic Characterization of Swine H1N2 Influenza Viruses Isolated from Korean Pigs / Journal of Microbiology and Biotechnology 17 (5) : 8
KIM, DOCKYU / 2006 / Analysis of a Prodigiosin Biosynthetic Gene Cluster from the Marine Bacterium Hahella chejuensis KCTC 2396 / Journal of Microbiology and Biotechnology 16
Ericsson, T. A. / 2003 / Identification of receptors for pig endogenous retrovirus. Proc. Natl. Acad / Sci 100 : 6759 ~ 6764
Harrison, I. / 2004 / Determinants of high titer in recombinant porcine endogenous retroviruses / Virol 78 : 13871 ~ 13879
JO, SU KYOUNG / 2007 / Genetic and Antigenic Characterization of Swine H1N2 Influenza Viruses Isolated from Korean Pigs / Journal of Microbiology and Biotechnology 17 (5) : 8
KIM, DOCKYU / 2006 / Analysis of a Prodigiosin Biosynthetic Gene Cluster from the Marine Bacterium Hahella chejuensis KCTC 2396 / Journal of Microbiology and Biotechnology 16
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
C형 돼지 내인성 레트로바이러스(PERV)의 C-말단 외막당단백질에 의한 재조합 PERV-A/C의 감염력 조절
미생물학회지
2010 .03
-
Construction of the Porcine Endogenous Retrovirus Envelope Glycoprotein A and B Specific Antibody
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2009 .06
-
무균돼지에 존재하는 내인성 레트로 바이러스 PERV-A와 PERV-B Envelope 유전자 클로닝
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2004 .12
-
Isolation and Characterization of PERV-C env from Domestic Pig in Korea
Journal of Microbiology and Biotechnology
2008 .01
-
Analysis of env Subtypes of Porcine Endogenous Retrovirus in SNU Miniature Pigs
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2014 .03
-
Evaluation of the Potential Risk of Porcine Endogenous Retrovirus (PERV) Infection in Nude Mice
Journal of Microbiology and Biotechnology
2011 .01
-
Identification and Characterization of PERV Elements in Different Pig Genome
한국생명과학회 심포지움
2006 .09
-
국내 돼지에서 분리한 내인성 레트로 바이러스 gag 유전자의 분자 생물학적 특성 분석
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2006 .09
-
Development of The Highly Efficient Packaging Viral Vector System Using PERV psi Sequence
한국미생물학회 학술대회논문집
2009 .05
-
Comparison of the Effects of Retroviral Restriction Factors Involved in Resistance to Porcine Endogenous Retrovirus
Journal of Microbiology and Biotechnology
2014 .01
-
Enhancement of Short-Circuit Current Density in Solar Cells via Reducing Recombination
한국진공학회 학술발표회초록집
2014 .02
-
KNOTTED AND LINKED PRODUCTS OF RECOMBINATION ON T(2,n)#T(2,m) SUBSTRATES
대한수학회지
2014 .01
-
Identification and Expression of Human Endogenous Retrovirus HERV-W, in Human Tissues and Cancer Cells
한국동물학회 학술대회
2003 .01
-
Human-specific Insertion of Human Endogenous Retrovirus K (HERV-K) Generate Human Genomic Variation
한국미생물학회 학술대회논문집
2011 .05
-
Molecular Cloning and Phylogenetic Analysis of New Human Endogenous Retrovirus HERV-W Family In Cancer Cells
한국동물학회 학술대회
2001 .01
-
Identification and Phylogeny of Long Terminal Repeat Elements of Human Endogenous Retrovirus HERV-S
한국동물학회 학술대회
2001 .01
-
Postentry Inhibition of Porcine Endogenous Retrovirus by Human Trim5 alpha Protein
한국미생물학회 학술대회논문집
2009 .05
-
Transformation-associated recombination cloning에 의한 유전자 분리에 사용되는 target hook에 대한 GC content의 영향
미생물학회지
2003 .09
-
인간 내성 리트로 바이러스(HERV)와 인간 면역 결핍 바이러스(HIV)의 상관관계
생명과학회지
2015 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0