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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 270 - 282 (13page)
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초록· 키워드
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The yeast Saccharomyces cerevisiae has defense mechanisms identical to higher eukaryotes. It offers the potential for genome-wide experimental approaches owing to its smaller genome size and the availability of the complete sequence.
It therefore represents an ideal eukaryotic model for studying cellular redox control and oxidative stress responses.
S. cerevisiae Yap1 is a well-known transcription factor that is required for H2O2-dependent stress responses. Yap1 is involved in various signaling pathways in an oxidative stress response. The Gpx3 (Orp1/PHGpx3) protein is one of the factors related to these signaling pathways. It plays the role of a transducer that transfers the hydroperoxide signal to Yap1. In this study, using extensive proteomic and bioinformatics analyses, the function of the Gpx3 protein in an adaptive response against oxidative stress was investigated in wild-type, gpx3-deletion mutant, and gpx3-deletion mutant overexpressing Gpx3 protein strains.
We identified 30 proteins that are related to the Gpx3- dependent oxidative stress responses and 17 proteins that are changed in a Gpx3-dependent manner regardless of oxidative stress. As expected, H2O2-responsive Gpx3- dependent proteins include a number of antioxidants related with cell rescue and defense. In addition, they contain a variety of proteins related to energy and carbohydrate metabolism, transcription, and protein fate. Based upon the experimental results, it is suggested that Gpx3-dependent stress adaptive response includes the regulation of genes related to the capacity to detoxify oxidants and repair oxidative stress-induced damages affected by Yap1 as well as metabolism and protein fate independent from Yap1.
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참고문헌 (23)
참고문헌 신청
Basu, U. / 2004 / Reverse genetic analysis of the glutathione metabolic pathway suggests a novel role of PHGPX and URE2 genes in aluminum resistance in Saccharomyces cerevisi
Baudin, A. / 1993 / A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucl / Acids Res 21 : 3329 ~ 3330
Brombacher, K. / 2006 / The role of Yap1p and Skn7p-mediated oxidative stress response in the defense of Saccharomyces cerevisiae against singlet oxygen / Yeast 23 : 741 ~ 75
Caesar, R. / 2006 / Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Euk / Cell 5 : 368 ~ 378
Carmel-Harel, O. / 2001 / Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae. Mol / Microbiol 39 : 595 ~ 605
Baudin, A. / 1993 / A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucl / Acids Res 21 : 3329 ~ 3330
Brombacher, K. / 2006 / The role of Yap1p and Skn7p-mediated oxidative stress response in the defense of Saccharomyces cerevisiae against singlet oxygen / Yeast 23 : 741 ~ 75
Caesar, R. / 2006 / Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Euk / Cell 5 : 368 ~ 378
Carmel-Harel, O. / 2001 / Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae. Mol / Microbiol 39 : 595 ~ 605
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