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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제6호
- 발행연도
- 2006.1
- 수록면
- 927 - 932 (6page)
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초록· 키워드
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Sbiomolecule serving mainly as a methyl donor. Our recentstudies revealed that SAM controls antibiotic production inStreptomyces. In this study, the functional mode of SAM wasstudied in S. coelicolor and S. antibioticus ATC11891,employing S-adenosylhomocysteine (SAH), a methylationreaction product of SAM. Actinorhodin biosynthesis did notrequire SAM as a methyl donor, whereas SAH enhanced theand the most effective concentration of SAH was higherthan that of SAM. In the case of oleandomycin that requiresSAM for its biosynthesis, both SAM and SAH at theconcentration as low as 100 mM showed comparable efficacyin enhancing the production; SAM at 1 mM concentrationaditionally stimulated to give a 5-fold enhancement ofoleandomycin production. In vitro autophosphorylation ofprotein kinase AfsK was found to be activated by both SAMand SAH, as well as other structurally related compounds.biosynthesis in a mode independent of its role as a methyldonor and sugest that SAM acts directly as an intracellularsignaling molecule for Streptomyces.
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참고문헌 (22)
참고문헌 신청
Cai, J. X / 1996 / Changes in S-adenosylmethionine synthetase in human liver cancer: Molecular characterization and significance / Hepatology 24 : 1090 ~ 1097
Chiang, P. K / 1996 / SAdenosylmethionine and methylation / FASEB J. 10 : 471 ~ 480
Demain, A. L / 1998 / Microbial natural products: Alive and well in 1998 / Nat. Biotechnol. 16 : 3 ~ 4
Fontecave, M / 2004 / Sadenosylmethionine: Nothing goes to waste / Trends. Biochem. Sci. 29 : 243 ~ 249
Gaisser, S / 2001 / New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster / Mol. Microbio
Chiang, P. K / 1996 / SAdenosylmethionine and methylation / FASEB J. 10 : 471 ~ 480
Demain, A. L / 1998 / Microbial natural products: Alive and well in 1998 / Nat. Biotechnol. 16 : 3 ~ 4
Fontecave, M / 2004 / Sadenosylmethionine: Nothing goes to waste / Trends. Biochem. Sci. 29 : 243 ~ 249
Gaisser, S / 2001 / New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster / Mol. Microbio
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S-Adenosyl-L-Methionine Analogues to Enhance the Production of Actinorhodin
Journal of Microbiology and Biotechnology
2006 .01
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고호모시스테인혈증 임신 흰쥐에서 엽산보충이 혈장 호모시스테인, Thiobarbituric Acid Reactive Substances (TBARS) 수준과 간의 SAM/SAH에 미치는 영향
한국영양학회지
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Pleiotrophic Effect of a Gene Fragment Conferring H2O2-resistance in Streptomyces coelicolor
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[해설]AES/SAM을 이용한 표면분석
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Genetic Characterization of Two S-Adenosylmethionine-induced ABCTransporters Reveals Their Roles in Modulations of Secondary Metabolismand Sporulation in Streptomyces coelicolor M145
Journal of Microbiology and Biotechnology
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엽산과 비타민 B₁₂ 결핍에 의한 호모시스테인혈증 흰쥐의 조직내 비타민 지표간의 상관관계 분석
한국영양학회지
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Thermal Behavior of Self - Assembled Monolayers (SAMs)
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S-adenosylmethionine(SAM)으로부터 Ethylene과 polyamine 생합성의 경쟁성에 관한 연구
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Streptomyces coelicolor의 Catalase 들의 분석
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Engineering of Primary Carbohydrate Metabolism for Increased Production of Antibiotic Production in Streptomyces coelicolor M510 and M145
한국미생물학회 학술대회논문집
2006 .05
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S-Adenosyl-L-methionine ameliorates TNFα-induced insulin resistance in 3T3-L1 adipocytes
Experimental and Molecular Medicine
2010 .01
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엽산 보충이 호모시스틴 식이에 의해 유발된 고호모시스테인혈증과 간의 S-Adenosylmethionine 대사에 미치는 영향
한국영양학회지
2003 .10
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Nitrate Transport in Streptomyces coelicolor
한국미생물학회 학술대회논문집
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Adsorption behavior of V₂O5 nanowires on mixed SAMs with different terminal groups
한국진공학회 학술발표회초록집
2005 .02
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Novel Vancomycin Resistance System in Streptomyces coelicolor
한국미생물학회 학술대회논문집
2005 .05
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Streptomyces coelicolor A3(2)의 유도기에서 성장인자 요구성의 교대현상
미생물학회지
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Streptomyces coelicolor의 발아과정 중 RNA와 단백질 합성의 주기적 변화
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$H_2O_2$ stress에 대한 Streptomyces coelicolor A3(2)의 저항성과 지방산의 변화
한국동물학회 학술대회
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Fabrication of SAMs/TiO₂ Hybrid Thin Films by Using Molecular Layer Deposition as the New Method
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2006 .02
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A System Development of the Protoplast Fusion of Streptomyces coelicolor
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