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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제1호
- 발행연도
- 2006.1
- 수록면
- 126 - 135 (10page)
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The Rev binding to Rev Responsive Elementviral replication cycle. The disruption of the Rev-RREinteraction has ben studied extensively in order to develop apotential antiviral drug. In order to provide the basis for amore promising approach to develop a Rev-RRE bindinginhibitor against HIV-1 infection, it is necesary to understandthe binding modes of the aminoglycoside antibiotics to RRE.In the present study, the binding mode of a modified antibiotic,a neamine conjugated with pyrene and arginine (NCPA), tom measurement andspectroscopic analysis of RRE with or without antibiotics.The results confirmed that NCPA competes with Rev inbinding to RRE.
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