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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제9호
- 발행연도
- 2008.1
- 수록면
- 1,584 - 1,589 (6page)
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초록· 키워드
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Although resistance of Helicobacter pylori to clarithromycin
is a major cause of failure of eradication therapies, little
information is available regarding gene mutations of
clarithromycin-resistant primary and secondary H. pylori
isolates in Korea. In the present study, we examined gene
mutations of H. pylori 23S rRNA responsible for resistance
to clarithromycin. DNA sequences of the 23S rRNA gene
in 21 primary clarithromycin-resistant and 64 secondary
clarithromycin-resistant strains were determined by PCR
amplification and nucleotide sequence analyses. Two
mutations of the 23S rRNA gene, A2143G and T2182C,
were observed in primary clarithromycin-resistant isolates.
In secondary isolates, dual mutation of A2143G+T2182C
was frequently observed. In addition, A2143G+T2182C+
T2190C, A2143G+T2182C+C2195T, and A2143G+T2182C
+A2223G were observed in secondary isolates. Furthermore,
macrolide binding was tested on purified ribosomes
isolated from T2182C or A2143C mutant strains with
[14C]erythromycin. Erythromycin binding increased in
a dose-dependent manner for the susceptible strain
but not for the mutant strains. These results indicate
that secondary isolates show a greater variety of 23S
rRNA gene mutation types than primary isolates, and
triple mutations of secondary isolates are associated
with A2143G+T2182C in H. pylori isolated from Korean
patients.
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참고문헌 (21)
참고문헌 신청
Adamek, R. J. / 1998 / Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole, and amoxicillin - influence on treatment outcome. Am. J / Gastroe
Burucoa, C. / 2005 / T2182C mutation is not associated with clarithromycin resistance in Helicobacter pylori. Antimicrob / Agents Chemother 49 (868)
De Francesco, V. / 2006 / Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. Ann. Intern / Med 144 : 94 ~ 100
Doucet-Populaire, F. / 1995 / Acquired resistance in Mycobacterium avium complex strains isolated from AIDS patients and beige mice during treatment with clarithromycin. J. A
Fontana, C. / 2002 / New site of modification of 23S rRNA associated with clarithromycin resistance of Helicobacter pylori clinical isolates. Antimicrob / Agents Chemother 46
Burucoa, C. / 2005 / T2182C mutation is not associated with clarithromycin resistance in Helicobacter pylori. Antimicrob / Agents Chemother 49 (868)
De Francesco, V. / 2006 / Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. Ann. Intern / Med 144 : 94 ~ 100
Doucet-Populaire, F. / 1995 / Acquired resistance in Mycobacterium avium complex strains isolated from AIDS patients and beige mice during treatment with clarithromycin. J. A
Fontana, C. / 2002 / New site of modification of 23S rRNA associated with clarithromycin resistance of Helicobacter pylori clinical isolates. Antimicrob / Agents Chemother 46
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