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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제3호
발행연도
2004.1
수록면
532 - 539 (8page)

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For efficient lincomycin production from Streptomyceslincolnensis L1245, various vegetable oils, natural nitrogensources, and surfactants were investigated at the pilot-scalelevel in the flask. Olive oil as the sole carbon source was themost suitable one for producing lincomycin. When 20 g/l ofolive oil was used, the lincomycin concentration and lipaseactivity reached 1.01 g/l and 182 U/ml, respectively, after5 days of culture. Among the various unsaturated fatty acids,when linolenic acid was used, the cell growth and lincomycinproduction were markedly decreased. On the other hand,when 0.2 g/l of oleic acid was added to the culture broth, themaximum lincomycin concentration was 1.0 g/l, which wasabout 1.7-fold higher than that obtained without the additionof oleic acid. Among the various natural nitrogen sources,pharmamedia or soybean meal was the most suitable nitrogensource. In particular, in the case of a mixture of 10 g/l ofpharmamedia and soybean meal, 1.5 g/l of lincomycinconcentration and 220 U/ml of lipase activity were obtained.When Span 180 was used as the surfactant, lincomycinproduction, lipase activity, and oil consumption increased.The correlation between the consumption rates of oil andlincomycin production in a culture using olive oil as the solecarbon source was also investigated. The lincomycin productiondepended on the consumption rate of olive oil. Using theseresults, fed-batch cultures for comparing the use of olive oiland starch as a conventional carbon source were carried out ina 5-l fermentor. When olive oil was used as the sole carbonsource, 34 g/l of olive oil was consumed after 7 days ofculture. The maximum lincomycin concentration was 3.0 g/l,which was about 2.0-fold higher than that of starch mediumafter 7 days of culture. The product yield was 0.09 g/g ofconsumed carbon source, which was about 3.0-fold higherthan that of starch medium after 7 days of culture.
#Olive oil #lincomycin #Streptomyces lincolnensisThe biosynthesis of most antibiotics is strongly regulatedby the nature and the concentration of carbon #nitrogen #phosphorus #and trace elements [11 #28]. It has beenreported that high concentr

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참고문헌 (25)

참고문헌 신청
Bader / 1984 / Sterilization of oils Data to support the use of acontinuous point-of-use-sterilizer : 848 ~ 856 google schola Behere, A. S / 2002 / Purification and characterization of lipase from theanaerobic lipolytic bacterium Selenomonas lipolytica 12 : 142 ~ 144 google schola Benslimane, C / 1995 / Influence of dextrins on the assimilationof yeast extract amino acid in culture of Streptomycesambafaciens producer of spiramycin 17 : 1003 ~ 1013 google schola Chang / 1980 / Pitfalls in the useof commercial nonionic detergents for the solubilizationof integral membrane proteins : 112 ~ 117 google schola Choi / 1996 / Efficient tylosin production fromStreptomyces fradiae using rapeseed oil 82 : 183 ~ 186 google schola

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