지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 275 - 280 (6page)
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초록· 키워드
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The role of alveolar macrophages (AMs) in the pathogenesis of asthma is still unknown. The aim of the present study was to investigate the effects of AM in the murine model of asthma. AMs were selectively depleted by liposomes containing clodronate just before allergen challenges, and changes in inflammatory cells and cytokine concentrations in bronchoalveolar lavage (BAL) fluid were measured. AMs were then adoptively transferred to AM-depleted sensitized mice and changes were measured. Phenotypic changes in AMs were evaluated after in vitro allergen stimulation.
AM-depletion after sensitization significantly increased the number of eosinophils and lymphocytes and the concentrations of IL-4, IL-5 and GM-CSF in BAL fluid. These changes were significantly ameliorated only by adoptive transfer of unsensitized AMs, not by sensitized AMs. In addition, in vitro allergen stimulation of AMs resulted in their gaining the ability to produce inflammatory cytokines, such as IL-1β, IL-6and TNF-α, and losing the ability to suppress GM-CSF concentrations in BAL fluid. These findings suggested that AMs worked probably through GM-CSF-dependent mechanisms, although further confirmatory experiments are needed. Our results indicate that the role of AMs in the context of airway inflammation should be re-examined.
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참고문헌 (16)
참고문헌 신청
Busse WW / 2001 / Asthma / N Engl J Med 344 : 350 ~ 362
Careau E / 2006 / Antigen sensitization modulates alveolar macrophage functions in an asthma model / Am J Physiol Lung Cell Mol Physiol 290 : L871 ~ L879
Careau E / 2010 / Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels / Exp Lung Res 36 : 255 ~ 261
Elder AC / 2004 / Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate / Exp Lung Res 30 : 105 ~ 120
Gosset P / 1991 / Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction /
Careau E / 2006 / Antigen sensitization modulates alveolar macrophage functions in an asthma model / Am J Physiol Lung Cell Mol Physiol 290 : L871 ~ L879
Careau E / 2010 / Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels / Exp Lung Res 36 : 255 ~ 261
Elder AC / 2004 / Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate / Exp Lung Res 30 : 105 ~ 120
Gosset P / 1991 / Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction /
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