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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 15 - 23 (9page)
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Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle. However, the role of BLVRA in the aging process remains unclear.
To study the role of BLVRA in the aging process, we compared the stress responses of young and senescent human diploid fibroblasts (HDFs) to the reactive oxygen species (ROS) inducer, hydrogen peroxide (H2O2). H2O2 markedly induced BLVRA activity in young HDFs, but not in senescent HDFs. Additionally,depletion of BLVRA reduced the H2O2-dependent induction of heme oxygenase-1 (HO-1) in young HDFs,but not in senescent cells, suggesting an aging-dependent differential modulation of responses to oxidative stress. The role of BLVRA in the regulation of cellular senescence was confirmed when lentiviral RNAitransfected stable primary HDFs with reduced BLVRA expression showed upregulation of the CDK inhibitor family members p16, p53, and p21, followed by cell cycle arrest in G0-G1 phase with high expression of senescence-associated β-galactosidase. Taken together,these data support the notion that BLVRA contributes significantly to modulation of the aging process by adjusting the cellular oxidative status.
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참고문헌 (24)
참고문헌 신청
Aggeli IK / 2006 / Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells / Cell Signal 18 : 1801 ~ 1812
Ahmad Z / 2002 / Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress /
Alcorta DA / 1996 / Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts / Proc Natl Acad Sci 93 : 13742 ~ 1
Baranano DE / 2002 / Snyder SH. Biliverdin reductase: a major physiologic cytoprotectant / Proc Natl Acad Sci USA 99 : 16093 ~ 16098
Beale SI / 1984 / Enzymatic heme oxygenase activity in soluble extracts of the unicellular red alga, Cyanidium caldarium / Arch Biochem Biophys 235 : 371 ~ 384
Ahmad Z / 2002 / Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress /
Alcorta DA / 1996 / Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts / Proc Natl Acad Sci 93 : 13742 ~ 1
Baranano DE / 2002 / Snyder SH. Biliverdin reductase: a major physiologic cytoprotectant / Proc Natl Acad Sci USA 99 : 16093 ~ 16098
Beale SI / 1984 / Enzymatic heme oxygenase activity in soluble extracts of the unicellular red alga, Cyanidium caldarium / Arch Biochem Biophys 235 : 371 ~ 384
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