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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 559 - 565 (7page)
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초록· 키워드
오류제보하기
Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate.
T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P ＜ .0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bonaa KH / 1992 / Association between heart-rate and atherogenic blood lipid fractions in a population - the Tromso Study / Circulation 86 : 394 ~ 405
Brasel KJ / 2007 / Heart rate: Is it truly a vital sign? / Journal of Trauma-Injury Infection and Critical Care 62 : 812 ~ 7
Cecconi M / 2005 / Mutation analysis of the NSD1 gene in a group of 59 patients with congenital overgrowth / American Journal of Medical Genetics Part A 134 : 247 ~ 53
Chen CC / 2003 / Abnormal coronary function in mice deficient in alpha(1H) T-type Ca2+ channels / Science 302 : 1416 ~ 8
Colhoun HM / 2001 / The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification - A study in type 1 diabetic patients and the
Brasel KJ / 2007 / Heart rate: Is it truly a vital sign? / Journal of Trauma-Injury Infection and Critical Care 62 : 812 ~ 7
Cecconi M / 2005 / Mutation analysis of the NSD1 gene in a group of 59 patients with congenital overgrowth / American Journal of Medical Genetics Part A 134 : 247 ~ 53
Chen CC / 2003 / Abnormal coronary function in mice deficient in alpha(1H) T-type Ca2+ channels / Science 302 : 1416 ~ 8
Colhoun HM / 2001 / The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification - A study in type 1 diabetic patients and the
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