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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 574 - 582 (9page)
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Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are in-volved in neuronal death. However, the effect of altered calcium homeostasis on the SOD1 aggregation is unknown. To investigate whether calcium triggers mu-tant SOD1 aggregation in vitro, human mutant SOD1 (G93A) was transfected into motor neuronal cell line cium ionophore A23187 or agents that induce intra-celular calcium release like cyclic ADP ribose, ryano-dine or thapsigargin. A23187 was found to increase mutant SOD1 aggregation and neuronal nitric oxide synthase (nNOS) expression. Moreover, the NOS in-hibitor (L-NAME) and a NO-dependent cyclic GMP cas-cade inhibitor (ODQ) reduced SOD1 aggregation, whereas an exogenous NO donor (GSNO) increased by NOS or cGMP cascade inhibitor. Our data demon-strate that calcium-influx increases SOD1 aggregation by upregulating NO in cultured motor neuronal cells.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ / Biological applications of ionophores : 501 ~ 30
Alexianu ME / / The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis : 846 ~ 58
Anneser JM / 2001 / Glial cells of the spinal cord and subcortical white matter up-regulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis 171 : 418
Atlante A / 1997 / Glutamate neurotoxicity in rat cerebellar granule cells a major role for xanthine oxidase in oxygen radical formation 68 ( ) : 2038 ~ 2045
Blottner D / 2001 / Just in time and place: NOS/NO system assembly in neuromuscular junction formation 55 : 171 ~ 180
Alexianu ME / / The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis : 846 ~ 58
Anneser JM / 2001 / Glial cells of the spinal cord and subcortical white matter up-regulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis 171 : 418
Atlante A / 1997 / Glutamate neurotoxicity in rat cerebellar granule cells a major role for xanthine oxidase in oxygen radical formation 68 ( ) : 2038 ~ 2045
Blottner D / 2001 / Just in time and place: NOS/NO system assembly in neuromuscular junction formation 55 : 171 ~ 180
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