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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 학술저널
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- 2014.1
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Mitochondrial functions are essential for the survival and function of neurons. Recently, it has been demonstrated that mitochondrial functions are highly associated with mitochondrial morphology, which is dynamically changed by the balance between fusion and fission. Mitochondrial morphology is primarily controlled by the activation of dynamin-related proteins including dynamin-related protein 1 (Drp1), which promotes mitochondrial fission. Drp1 activity is regulated by several posttranslational modifications, thereby modifying mitochondrial morphology. Here, we found that phosphorylation of Drp1 at serine 616 (S616) is mediated by cyclin-dependent kinase 5 (CDK5) in post-mitotic rat neurons. Perturbation of CDK5 activitymodified the level of Drp1S616 phosphorylation and mitochondrial morphology in neurons. In addition, phosphorylated Drp1S616 preferentially localized as a cytosolic monomer compared with total Drp1. Furthermore, roscovitine, a chemical inhibitor of CDKs, increased oligomerization and mitochondrial translocation of Drp1, suggesting that CDK5-dependent phosphorylation of Drp1 serves to reduce Drp1’s fission-promoting activity. Taken together, we propose that CDK5 has a significant role in the regulation of mitochondrial morphology via inhibitory phosphorylation of Drp1S616 in post-mitotic neurons.
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참고문헌 (25)
참고문헌 신청
Almeida A / 2005 / Cdh1/Hct1-APC is essential
Chan DC / 2006 / Mitochondrial fusion and fission in mammals / Annu Rev Cell Dev Biol 22 : 79 ~ 99
Cheng A / 2012 / Involvement of PGC-1alpha in the formation and maintenance of neuronal dendritic spines / Nat Commun : 1250 ~
Choi SY / 2013 / Drp1-mediated mitochondrial dynamics and survival of developing chick motoneurons during the period of normal programmed cell death / FASEB J 27 : 51 ~ 62
Dikov D / 2011 / How to split up : lessons from mitochondria / Embo J 30 : 2751 ~ 2753
Chan DC / 2006 / Mitochondrial fusion and fission in mammals / Annu Rev Cell Dev Biol 22 : 79 ~ 99
Cheng A / 2012 / Involvement of PGC-1alpha in the formation and maintenance of neuronal dendritic spines / Nat Commun : 1250 ~
Choi SY / 2013 / Drp1-mediated mitochondrial dynamics and survival of developing chick motoneurons during the period of normal programmed cell death / FASEB J 27 : 51 ~ 62
Dikov D / 2011 / How to split up : lessons from mitochondria / Embo J 30 : 2751 ~ 2753
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