지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 492 - 502 (11page)
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초록· 키워드
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Adequate assessment of plaque deposition levels in the brain of mouse models of Alzheimer disease (AD)is required in many core issues of studies on AD, including studies on the mechanisms underlying plaque pathogenesis, identification of cellular factors modifying plaque pathology, and developments of anti-AD drugs. The present study was undertaken to quantitatively evaluate plaque deposition patterns in the brains of the two popular AD models, Tg2576 and Tg-APPswe/PS1dE9 mice. Coronally-cut brain sections of Tg2576and Tg-APPswe/PS1dE9 mice were prepared and plaque depositions were visualized by staining with anti-amyloid β peptides antibody. Microscopic images of plaque depositions in the prefrontal cortex, parietal cortex, piriform cortex and hippocampus were obtained and the number of plaques in each region was determined by a computer-aided image analysis method. A series of optical images representing a gradual increase of plaque deposition levels were selected in the four different brain regions and were assigned in each with a numerical grade of 1-6, where +1 was lowest and +6, highest, so that plaques per unit in mm2 increased “sigmoidally” over the grading scales.
Analyzing plaque depositions using the photographic plaque reference panels and a computer-aid image analysis method, it was demonstrated that the brains of Tg2576 mice started to accumulate predominantly small plaques, while the brains of Tg-APPswe/PS1dE9mice deposited relatively large plaques.
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등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Bacher M / 2008 / CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease / J Exp Med 205 : 1593 ~ 1599
Benzing WC / 1999 / Evidence for glial mediated inflammation in aged APPsw transgenic mice / Neurobiol Aging 20 : 581 ~ 589
Flood DG / 2002 / FAD mutant PS-1 gene-targeted mice:increased Abeta 42 and Abeta deposition without APP overproduction / Neurobiol Aging 23 : 335 ~ 348
Ho A / 2008 / Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease / J Neurosci 28 : 14392 ~ 14400
Hsiao K / 1996 / Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice / Science 274 : 99 ~ 102
Benzing WC / 1999 / Evidence for glial mediated inflammation in aged APPsw transgenic mice / Neurobiol Aging 20 : 581 ~ 589
Flood DG / 2002 / FAD mutant PS-1 gene-targeted mice:increased Abeta 42 and Abeta deposition without APP overproduction / Neurobiol Aging 23 : 335 ~ 348
Ho A / 2008 / Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease / J Neurosci 28 : 14392 ~ 14400
Hsiao K / 1996 / Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice / Science 274 : 99 ~ 102
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