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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 185 - 194 (10page)
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Phytosphingosine-1-phosph ate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38 kinase, and these Moreover, PhS1P stimulated the chemotactic migra-tion of L2071 cells via PTX-sensitive Gi protein(s). In addition, the PhS1P-induced chemotactic mi-gration of L2071 cells was also dramatically inhibited by LY294002 and SB203580 (inhibitors of phos-phoinositide 3-kinase and p38 kinase, respectively). L2071 cells are known to express four S1P receptors, i.e., S1P1, S1P2, S1P3, and S1P4, and pretreatment with an S1P1 and S1P3 antagonist (VPC 23019) did not affect on PhS1P-induced chemotaxis. This study demonstrates that PhS1P stimulates at least two different signaling cascades,tive but phospholipase C dependent intracellular calcium increase, and the other is a PTX-sensitive chemotactic migration mediated by phosphoino-sitide 3-kinase and p38 kinase.
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참고문헌 (24)
참고문헌 신청
An S / 1997 / Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids 417 : 279 ~ 282
An S / 1998 / Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization 54 : 881 ~ 888
An S / 2000 / Sphingosine 1-phosphate-induced cell proliferation,survival,and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 275 : 288 ~ 296
Bae YS / 2003 / Differential activation of formyl peptide receptor-like 1 by peptide ligands 171 : 6807 ~ 6813
Candelore MR / 2002 / Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor 297 : 600 ~ 606
An S / 1998 / Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization 54 : 881 ~ 888
An S / 2000 / Sphingosine 1-phosphate-induced cell proliferation,survival,and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 275 : 288 ~ 296
Bae YS / 2003 / Differential activation of formyl peptide receptor-like 1 by peptide ligands 171 : 6807 ~ 6813
Candelore MR / 2002 / Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor 297 : 600 ~ 606
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