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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 391 - 398 (8page)
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PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. Its major function is likely to be the phosphatase activity that regulates the phosphoti-dylinositol (PI)3-kinase/ Akt pathway. On the other proliferation and cell survival via PI3-kinase/Akt and mitogen-activated protein kinase pathways in many cancer cells. To evaluate effect of PTEN on cell growth and IGF system in gastric cancer, human gastric adenocarcinoma cells (SNU-5 & -216) were transfected with human PTEN cDNA. Those PTEN- transfected gastric cancer cells had a lower pro-liferation rate than the pcDNA3-transfected cells. PTEN overexpression induced a profound decrease in the IGF-II and IGF-IR expression levels, and downregulation of IGF-II expression by PTEN was mediated through the regulation of the IGF-II pro-moter. In addition, a PI3-kinase inhibitor, LY294002, induced the downregulation of IGF-II expression. The PTEN-overexpressing SUN-5 and -216 cells were more sensitive to death induced by etoposide and pcDNA3-transfected cells. These findings suggest that PTEN suppresses the cell growth through modulation of IGF system and sensitizing cancer cells to cell death by anticancer drugs.
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참고문헌 (22)
참고문헌 신청
/ / -mediated signaling; the protein phosphataseactivity of PTEN downregulates IGF-II expression inhepatoma cells : 203 ~ 8
/ / Adenovirus transgene expression of MMAC/PTEN inglioma cells inhibits Akt activation and induces anoikis : 5285 ~ 90
/ / Cellular markers in the precancerous process : 91 ~ 109
/ / Enhanced expression ofinsulin-like growth factor binding protein-3 sensitizes thegrowth inhibitory effect of anticancer drugs in gastric cancercells : 480 ~ 6
/ / Growth suppressionof glioma cells by PTEN requires a functionalphosphatase catalytic domain : 12479 ~ 84
/ / Adenovirus transgene expression of MMAC/PTEN inglioma cells inhibits Akt activation and induces anoikis : 5285 ~ 90
/ / Cellular markers in the precancerous process : 91 ~ 109
/ / Enhanced expression ofinsulin-like growth factor binding protein-3 sensitizes thegrowth inhibitory effect of anticancer drugs in gastric cancercells : 480 ~ 6
/ / Growth suppressionof glioma cells by PTEN requires a functionalphosphatase catalytic domain : 12479 ~ 84
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