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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 545 - 550 (6page)
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초록· 키워드
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Corn silk has been purified as an anticoagulant previously and the active component is a poly-saccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric oxide synthase (NOS) and generate substantial amounts of NO in time and dose-dependent maners. It was detectable first at 15 h after stimulation by corn silk, peaked at 24 h, and undetectable by 48 h. Induction of NOS is in-hibited by pyrolidine dithiocarbamate (PDTC) and genistein, an inhibitor of nuclear factor kappa B (NF-κB) and tyrosine kinase, respectively, indi-cating that iNOS stimulated by corn silk is as-sociated with tyrosine kinase and NF-κB sig-naling pathways. IκB-α degradation was detec-tible at 10 min, and the level was restored at 120 min after treatment of corn silk. Corn silk induced nuclear translocation of NF-κB by phos-phorylation and degradation of IκB-α.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1908-13 / Expression of nitric oxide synthase gene inmouse macrophages activated for tumor cell killing
/ 1995 / Activation of NF-κB requiresproteolysis of the inhibitor of IκB-α : 552 ~ 6
/ 1996 / Analysis of the sugar specificity and molecular location ofthe β-glucan-binding lectin site of complement receptor type3 : 1235 ~ 46
/ 1998 / Extracts of corn silk inhibits the tumornecrosis factor-alpha- and bacterial lipopolysaccharideinducedcell adhesion and ICAM-1 expression : 314 ~ 8
/ 1998 / Inhibition of inducible nitric oxide synthase by peroxysomeproliferator-activated receptor agonists correlation withinduction of heme oxygenase 1 : 978 ~ 84
/ 1995 / Activation of NF-κB requiresproteolysis of the inhibitor of IκB-α : 552 ~ 6
/ 1996 / Analysis of the sugar specificity and molecular location ofthe β-glucan-binding lectin site of complement receptor type3 : 1235 ~ 46
/ 1998 / Extracts of corn silk inhibits the tumornecrosis factor-alpha- and bacterial lipopolysaccharideinducedcell adhesion and ICAM-1 expression : 314 ~ 8
/ 1998 / Inhibition of inducible nitric oxide synthase by peroxysomeproliferator-activated receptor agonists correlation withinduction of heme oxygenase 1 : 978 ~ 84
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