지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 149 - 158 (10page)
이용수
초록· 키워드
오류제보하기
The development of gastric cancer (GC) is closely related to chronic inflammation caused by Helicobacter pylori infection, and herpes virus entry mediator (HVEM) is a receptor expressed on the surface of leukocytes that mediates potent inflammatory responses in animal models. However, the role of HVEM in human GC has not been studied. Previously, we showed that the interaction of HVEM on human leukocytes with its ligand LIGHT induces intracellular calcium mobilization,which results in inflammatory responses including induction of proinflammatory cytokine production and anti-bacterial activities. In this study, we report that leukocytes from GC patients express lower levels of membrane HVEM (mHVEM) and have lower LIGHT-induced bactericidal activities than those from healthy controls (HC). In contrast, levels of soluble HVEM (sHVEM) in the sera of GC patients were significantly higher than in those of HC. We found that monocyte membrane-bound HVEM is released into the medium when cells are activated by proinflammatory cytokines such as TNF-α and IL-8, which are elevated in the sera of GC patients. mHVEM level dropped in parallel with the release of sHVEM, and release was completely blocked by the metalloprotease inhibitor,GM6001. We also found that the low level of mHVEM on GC patient leukocytes was correlated with low LIGHT-induced bactericidal activities against H. pylori and S. aureus and production of reactive oxygen species. Our results indicate that mHVEM on leukocytes and sHVEM in sera may contribute to the development and/or progression of GC.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Aggarwal BB / 2003 / Signaling pathways of the TNF superfamily: a double-edged sword / Nat Rev Immunol 3 : 745 ~ 756
Arribas J / 2002 / Protein ectodomain shedding / Chem Rev 102 : 4627 ~ 4638
Balkwill F / 2009 / Tumour necrosis factor and cancer / Nat Rev Cancer 9 : 361 ~ 371
Bass DA / 1983 / Flow cytometeric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation / J Immunol 130 : 1910 ~ 1917
Benucci M / 2011 / Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis / Int J Immunopat
Arribas J / 2002 / Protein ectodomain shedding / Chem Rev 102 : 4627 ~ 4638
Balkwill F / 2009 / Tumour necrosis factor and cancer / Nat Rev Cancer 9 : 361 ~ 371
Bass DA / 1983 / Flow cytometeric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation / J Immunol 130 : 1910 ~ 1917
Benucci M / 2011 / Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis / Int J Immunopat
이 논문의 저자 정보
최근 본 자료
댓글(0)
0