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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 73 - 80 (8page)
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초록· 키워드
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Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved in the autophagic pathway. Most of these autophagy genes are present in higher eukaryotes and regulate autophagy process for cell survival and homeostasis.
Significant progress has recently been made to better understand the molecular mechanisms of the autophagy machinery. Especially, autophagy process, including the regulation of autophagy induction through mTOR and the nucleation and elongation in autophagosome formation through class III phosphatidylinositol 3-kinase complex and ubiquitin-like conjugation systems, became evident. While many unanswered questions remain to be answered, here, we summarize the recent process of autophagy with emphasis on molecules and their protein complexes along with advanced molecular mechanisms that regulate the autophagy machinery.
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참고문헌 (29)
참고문헌 신청
Botti J / 2006 / Autophagy signaling and the cogwheels of cancer / Autophagy 2 : 67 ~ 73
Burman C / 2010 / Autophagosome formation in mammalian cells / Semin Immunopathol 32 : 397 ~ 413
Chen Y / 2011 / The regulation of autophagyunanswered questions / J Cell Sci 124 : 161 ~ 170
Crighton D / 2007 / DRAM links autophagy to p53 and programmed cell death / Autophagy 3 : 72 ~ 74
Cuervo AM / 2004 / Autophagy: In sickness and in health / Trends Cell Biol 14 : 70 ~ 77
Burman C / 2010 / Autophagosome formation in mammalian cells / Semin Immunopathol 32 : 397 ~ 413
Chen Y / 2011 / The regulation of autophagyunanswered questions / J Cell Sci 124 : 161 ~ 170
Crighton D / 2007 / DRAM links autophagy to p53 and programmed cell death / Autophagy 3 : 72 ~ 74
Cuervo AM / 2004 / Autophagy: In sickness and in health / Trends Cell Biol 14 : 70 ~ 77
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