지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1 - 6 (6page)
이용수
초록· 키워드
오류제보하기
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW,indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-b production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bae YS / 1999 / Trp-Lys-Tyr-Met- Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes / J Leukoc
Bae YS / 1999 / Trp-Lys-Tyr-Met-Val-DMet is a chemoattractant for human phagocytic cells / J Leukoc Biol 66 : 915 ~ 922
Bae YS / 2003 / Differential activation of formyl peptide receptor signaling by peptide ligands / Mol Pharmacol 64 : 841 ~ 847
Bae YS / 2004 / Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling / J Immunol 173 : 607 ~ 614
Baek SH / 1996 / Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries / J Biol Chem 271 : 8170 ~ 8175
Bae YS / 1999 / Trp-Lys-Tyr-Met-Val-DMet is a chemoattractant for human phagocytic cells / J Leukoc Biol 66 : 915 ~ 922
Bae YS / 2003 / Differential activation of formyl peptide receptor signaling by peptide ligands / Mol Pharmacol 64 : 841 ~ 847
Bae YS / 2004 / Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling / J Immunol 173 : 607 ~ 614
Baek SH / 1996 / Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries / J Biol Chem 271 : 8170 ~ 8175
이 논문의 저자 정보
최근 본 자료
댓글(0)
0