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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1 - 6 (6page)
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miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic sclerosis;SSc) is a highly heterogeneous autoimmune disease that includes the progressive fibrotic replacement of normal tissue architecture in multiple organs. Our previous studies have suggested that SSc skin tissues display a different miRNA expression signature than that found in normal controls. miRNAs with pro- or antifibrotic properties are found to be dysregulated in SSc skin fibrosis. Serum miRNA levels are associated with SSc activity and severity. miRNAs have the potential to be therapeutic targets and serve as biomarkers for SSc diagnosis and assessment of disease state and severity. This review summarizes the SSc miRNA expression signature and the roles of dysregulation of miRNAs in SSc tissues and serum and examines the future therapeutic potential of targeting miRNAs in the management of SSc patients.
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참고문헌 (27)
참고문헌 신청
Alevizos I / 2010 / MicroRNAs as biomarkers in rheumatic diseases / Nat Rev Rheumatol 6 : 391 ~ 398
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Bhattacharyya S / 2012 / Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities / Nat Rev Rheumatol 8 : 42 ~ 54
Bushati N / 2007 / microRNA functions / Annu Rev Cell Dev Biol 23 : 175 ~ 205
Carrington JC / 2003 / Role of microRNAs in plant and animal development / Science 301 : 336 ~ 338
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Bhattacharyya S / 2012 / Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities / Nat Rev Rheumatol 8 : 42 ~ 54
Bushati N / 2007 / microRNA functions / Annu Rev Cell Dev Biol 23 : 175 ~ 205
Carrington JC / 2003 / Role of microRNAs in plant and animal development / Science 301 : 336 ~ 338
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