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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 학술저널
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- 2013.1
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This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer’s disease (AD)). Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain sitespecific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. Of these proteins, 31 were significantly altered. Most of the differentially regulated proteins are involved in molecular transport, nervous system development, synaptic plasticity and apoptosis. Particularly, proteins such as Gelsolin (GSN), Tenascin-R (TNR) and AHNAK could potentially act as novel biomarkers of aging-related neurodegeneration. Importantly, our Ingenuity Pathway Analysis (IPA)-based network analysis further revealed ubiquitin C (UBC) as a pivotal protein to interact with diverse AD-associated pathophysiological molecular factors and suggests the reduced ubiquitin proteasome degradation system (UPS) as one of the causative factors of AD.
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참고문헌 (26)
참고문헌 신청
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Andersen K / 2012 / Stereological quantification of the cerebellum in patients with Alzheimer’s disease / Neurobiol Aging 33 : e111 ~ e120
Ballatore C / 2007 / Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders / Nat Rev Neurosci 8 : 663 ~ 672
Braak H / 1991 / Neuropathological stageing of Alzheimer-related changes / Acta Neuropathol 82 : 239 ~ 259
Ciavardelli D / 2010 / Alterations of brain and cerebellar proteomes linked to Abeta and tau pathology in a female triple-transgenic murine model of Alzheimer’s disease / C
Andersen K / 2012 / Stereological quantification of the cerebellum in patients with Alzheimer’s disease / Neurobiol Aging 33 : e111 ~ e120
Ballatore C / 2007 / Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders / Nat Rev Neurosci 8 : 663 ~ 672
Braak H / 1991 / Neuropathological stageing of Alzheimer-related changes / Acta Neuropathol 82 : 239 ~ 259
Ciavardelli D / 2010 / Alterations of brain and cerebellar proteomes linked to Abeta and tau pathology in a female triple-transgenic murine model of Alzheimer’s disease / C
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