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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 361 - 366 (6page)
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초록· 키워드
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Cytochrome P450 1A1 (CYP1A1) is involved in the 2- hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We eval-uated the associations between two CYP1A1phisms [MspI (rs4646903); Ile462Val (rs1048943)] and breast cancer in a multicenter case-control study of 513 breast cancer cases and 447 controls in Korea. Women carrying the T allele of the CYP1A1 MspI polymorphism were found to have a 1.72-fold (95% CI 1.11-2.68) greater risk of developing breast cancer. No association was found between any CYP1A1 Ile462Val polymorphism and breast cancer. Haplo-type analysis of the two loci showed that the CA haplotype was associated with the lowest risk of breast cancer, and CA/CA diplotypes were asso-ciated with a lower risk of breast cancer [OR = 0.28 (0.13-0.61)] than others/others diplotypes. Moreover, this reduced risk was more pronounced among women with a lower body mass index (BMI) [OR = 0.18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR = 0.23 (0.07-0.81)suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer.
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참고문헌 (24)
참고문헌 신청
Ambrosone CB / 1995 / Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmeno-pausal breast cancer risk 55 : 3483 ~ 3485
Bailey LR / 1998 / Breast cancer and CYPIA1, GSTM1, and GSTT1 polymor-phisms: evidence of a lack of association in Caucasians and African Americans 58 : 65 ~ 70
Basham VM / 2001 / Polymorphisms in CYP1A1 and smoking no association with breast cancer risk 22 : 1797 ~ 1800
Boyapati SM / 2005 / Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women 103 : 2228 ~ 2235
Cavalieri EL / 2001 / Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol implications for estrogen-induced initiation of renal tumors 14
Bailey LR / 1998 / Breast cancer and CYPIA1, GSTM1, and GSTT1 polymor-phisms: evidence of a lack of association in Caucasians and African Americans 58 : 65 ~ 70
Basham VM / 2001 / Polymorphisms in CYP1A1 and smoking no association with breast cancer risk 22 : 1797 ~ 1800
Boyapati SM / 2005 / Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women 103 : 2228 ~ 2235
Cavalieri EL / 2001 / Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol implications for estrogen-induced initiation of renal tumors 14
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