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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 316 - 326 (11page)
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6-Hydroxydopamine (6-OHDA) is a neurotoxin and is commonly used to generate experimental models of Parkinsons disease (PD). In this study, we investi-gated the signaling molecules involved in the 6- OHDA-induced cell death using a neuronal cate-cholaminergic cell line (SK-N-SH cells), and the protective effect of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-OHDA-induced neuronal y increased levels of reac-tive oxygen species (ROS), intracelular Ca2+ ([Ca2+]i), and p38 phosphorylation. In addition, this ROS increase by 6-OHDA was reduced by pretreatment with N-acetylcysteine (NAC), a free radical scavenger, but not by bis-(o-aminophenoxy)- ethane-N,N,N,N- tetraacetic acid (BAPTA), a Ca2+ chelator. However, the [Ca2+]i increase induced by 6-OHDA was su-ppressed by NAC. Moreover, pretreatment with NAC or BAPTA significantly prevented the 6-OHDA- Bcl-2 ratio, and caspase-3 activity. Although 6- OHDA-increased phosphorylation of p38 was pre-vented by NAC or BAPTA, inhibition of p38 by SB203580 did not suppress ROS, Bax/Bcl-2 ratio, or caspase-3 activity increases, and only partially prevented 6-OHDA-induced cell death, thus demon-strating that p38 activation is a component of a signaling pathway leading to the initiation of 6-OHDA-induced cell death, which acts in parallel with an ROS-Ca2+-Bcl-2-caspase-3 pathway. More-over, fustin not only suppressed 6-OHDA-induced cell death in a concentration-dependent manner but also blocked 6-OHDA-induced increases in ROS, [Ca2+]i, Bax/Bcl-2 ratio, caspase-3 activity, and p38 phosphorylation. These results suggest that fustin exerts neuroprotection against 6-OHDA-induced cell death.
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참고문헌 (25)
참고문헌 신청
Andrew R / / The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls : 1175 ~ 7
Armstrong JS / 2006 / The role of the mitochondrial permeability tran-sition in cell death 6 : 225 ~ 234
Auchon D / 2002 / Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation 9 : 423 ~ 432
Bae JH / 2003 / inhibitor of mi-tochondrial Ca2+ uniporter inhibits curcumin-induced apopto-sis via the prevention of intracellular Ca2+depletion and cyto-chrome c release. B
Beal MF / 2001 / Experimental models of Parkinson's disease 2 : 325 ~ 334
Armstrong JS / 2006 / The role of the mitochondrial permeability tran-sition in cell death 6 : 225 ~ 234
Auchon D / 2002 / Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation 9 : 423 ~ 432
Bae JH / 2003 / inhibitor of mi-tochondrial Ca2+ uniporter inhibits curcumin-induced apopto-sis via the prevention of intracellular Ca2+depletion and cyto-chrome c release. B
Beal MF / 2001 / Experimental models of Parkinson's disease 2 : 325 ~ 334
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