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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
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- 1 - 9 (9page)
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Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression in melanoma tissues with increasing tumor stage as well as metastasis; its expression is also negatively associated with melanoma patient survival. Furthermore, we demonstrate that miR-98 inhibits melanoma cell migration in vitro as well as metastatic tumor size in vivo. We also found that IL-6 is a target gene of miR-98, and IL-6 represses miR-98 levels via the Stat3-NF-κB-lin28B pathway. In an in vivo melanoma model, we demonstrate that miR-98 reduces melanoma metastasis and increases survival in part by reducing IL-6 levels; it also decreases Stat3 and p65 phosphorylation as well as lin28B mRNA levels. These results suggest that miR-98 inhibits melanoma metastasis in part through a novel miR-98-IL-6-negative feedback loop.
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참고문헌 (26)
참고문헌 신청
Baade P / 2005 / Trends in melanoma mortality in Australia : 1950?2002and their implications for melanoma control / Aust NZ J Public Health 29 : 383 ~ 386
Bar-Eli M / 2011 / Searching for the ‘melano-miRs’ : miR-214 drives melanoma metastasis / EMBO J 30 : 1880 ~ 1881
Bemis LT / 2008 / MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines / Cancer Res 68 : 1362 ~ 1368
Coory M / 2006 / Trends for in situ and invasive melanoma in Queensland, Australia, 1982?2002 / Cancer Causes Control 17 : 21 ~ 27
Fu TY / 2011 / Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells / Exp Cell Res 317 : 445 ~ 451
Bar-Eli M / 2011 / Searching for the ‘melano-miRs’ : miR-214 drives melanoma metastasis / EMBO J 30 : 1880 ~ 1881
Bemis LT / 2008 / MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines / Cancer Res 68 : 1362 ~ 1368
Coory M / 2006 / Trends for in situ and invasive melanoma in Queensland, Australia, 1982?2002 / Cancer Causes Control 17 : 21 ~ 27
Fu TY / 2011 / Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells / Exp Cell Res 317 : 445 ~ 451
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