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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Apoptosis has an important role in maintaining tissue homeostasis in cellular stress responses such as inflammation,endoplasmic reticulum stress, and oxidative stress. T-cell death-associated gene 51 (TDAG51) is a member of the pleckstrin homology-like domain family and was first identified as a pro-apoptotic gene in T-cell receptor-mediated cell death. However,its pro-apoptotic function remains controversial. In this study, we investigated the role of TDAG51 in oxidative stress-induced apoptotic cell death in mouse embryonic fibroblasts (MEFs). TDAG51 expression was highly increased by oxidative stress responses. In response to oxidative stress, the production of intracellular reactive oxygen species was significantly enhanced in TDAG51-deficient MEFs, resulting in the activation of caspase-3. Thus, TDAG51 deficiency promotes apoptotic cell death in MEFs, and these results indicate that TDAG51 has a protective role in oxidative stress-induced cell death in MEFs.
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참고문헌 (26)
참고문헌 신청
Fedoroff N / 2006 / Redox regulatory mechanisms in cellular stress responses / Ann Bot 98 : 289 ~ 300
Fulda S / 2006 / Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy / Oncogene 25 : 4798 ~ 4811
Gogna R / 2012 / ROS-mediated p53 core-domain modifications determine apoptotic or necrotic death in cancer cells / Antioxid Redox Signal 16 : 400 ~ 412
Gomes I / 1999 / A proline- and glutamine-rich protein promotes apoptosis in neuronal cells / J Neurochem 73 : 612 ~ 622
Gorman AM / 1996 / Oxidative stress and apoptosis in neurodegeneration / J Neurol Sci 139 (Suppl) : 45 ~ 52
Fulda S / 2006 / Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy / Oncogene 25 : 4798 ~ 4811
Gogna R / 2012 / ROS-mediated p53 core-domain modifications determine apoptotic or necrotic death in cancer cells / Antioxid Redox Signal 16 : 400 ~ 412
Gomes I / 1999 / A proline- and glutamine-rich protein promotes apoptosis in neuronal cells / J Neurochem 73 : 612 ~ 622
Gorman AM / 1996 / Oxidative stress and apoptosis in neurodegeneration / J Neurol Sci 139 (Suppl) : 45 ~ 52
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