지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 학술저널
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- 발행연도
- 2013.1
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3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore,BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-a and rosiglitazone. Here we investigated the function of BAFF in 3T3-L1 adipocytes and RAW 264.7 macrophages. We examined adipokine expression in 3T3-L1 adipocytes treated with 10 ng ml 1 BAFF. We also examined inflammatory molecule expression in RAW 264.7macrophages treated with 10 or 100 ng ml 1 BAFF. We examined BAFF expression in the coculture of 3T3-L1 adipocytes and RAW 264.7 macrophages, as well as in white adipose tissue (WAT) of diet-induced obese (DIO) mice. We found that BAFF decreases leptin and adiponectin expression, but increases the expression of proinflammatory adipokines monocyte chemotactic protein-1, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and haptoglobin. Coculturing the two cell types resulted in increased BAFF mRNA and protein expression, as well as modulation of BAFF-R mRNA expression in both cell types. These data indicate that BAFF might mediate adipocyte and macrophage interaction. When RAW 264.7 macrophages were treated with BAFF,BAFF-R expression was modulated as in coculture, and nitric oxide synthase and IL-6 expression increased. BAFF expression also increased in WAT of DIO mice. We propose that BAFF can regulate adipokine expression and possibly mediate adipocyte and macrophage interaction.
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참고문헌 (26)
참고문헌 신청
Alexaki VI / 2009 / Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of n
Arner P / 2005 / Insulin resistance in type 2 diabetes - role of the adipokines / Curr Mol Med 5 : 333 ~ 339
Beuther DA / 2006 / Obesity and asthma / Am J Respir Crit Care Med 174 : 112 ~ 119
Brennan AM / 2006 / Drug insight: the role of leptin in human physiology and pathophysiology emerging clinical applications / Nat Clin Pract Endocrinol Metab 2 : 318 ~ 327
Christopher SW / 1999 / The role of cyclooxygenases in inflammation, cancer, and development / Oncogene 18 : 7908 ~ 7916
Arner P / 2005 / Insulin resistance in type 2 diabetes - role of the adipokines / Curr Mol Med 5 : 333 ~ 339
Beuther DA / 2006 / Obesity and asthma / Am J Respir Crit Care Med 174 : 112 ~ 119
Brennan AM / 2006 / Drug insight: the role of leptin in human physiology and pathophysiology emerging clinical applications / Nat Clin Pract Endocrinol Metab 2 : 318 ~ 327
Christopher SW / 1999 / The role of cyclooxygenases in inflammation, cancer, and development / Oncogene 18 : 7908 ~ 7916
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