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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 61 - 68 (8page)
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Parathyroid hormone (PTH) treatment was previously shown to improve cardiac function after myocardial infarction by enhancing neovascularization and cell survival. In this study, pressure overload-induced left ventricular hypertrophy (LVH) was induced in mice by transverse aortic banding (TAB) for 2 weeks. We subsequently evaluated the effects of a 2-week treatment with PTH or saline on compensated LVH. After another 4 weeks, the hearts of the mice were analyzed by echocardiography,histology, and molecular biology. Echocardiography showed that hearts of the PTH-treated mice have more severe failing phenotypes than the saline-treated mice following TAB with a greater reduction in fractional shortening and left ventricular posterior wall thickness and with a greater increase in left ventricular internal dimension. Increases in the heart weight to body weight ratio and lung weight to body weight ratio following TAB were significantly exacerbated in PTH-treated mice compared to saline-treated mice. Molecular markers for heart failure,fibrosis, and angiogenesis were also altered in accordance with more severe heart failure in the PTH-treated mice compared to the saline-treated mice following TAB. In addition, the PTH-treated hearts were manifested with increased fibrosis accompanied by an enhanced SMAD2 phosphorylation. These data suggest that the PTH treatment may accelerate the process of decompensation of LV, leading to heart failure.
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참고문헌 (23)
참고문헌 신청
Anamourlis C / 2006 / Phosphodiesterase inhibition promotes the transition from compensated hypertrophy to cardiac dilatation in rats / Pflugers Arch 451 : 526 ~ 533
Chen MS / 2004 / Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis / J Mol Cell Cardiol 37 : 889 ~ 896
Clemens TL / 2001 / Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and
Dickstein K / 2008 / ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chron
Hardt SE / 2004 / Negative regulators of cardiac hypertrophy / Cardiovasc Res 63 : 500 ~ 509
Chen MS / 2004 / Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis / J Mol Cell Cardiol 37 : 889 ~ 896
Clemens TL / 2001 / Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and
Dickstein K / 2008 / ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chron
Hardt SE / 2004 / Negative regulators of cardiac hypertrophy / Cardiovasc Res 63 : 500 ~ 509
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