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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 1 - 11 (11page)
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Phospholipids are key components of cellular membrane and signaling. Among cellular phospholipids,phosphoinositides, phosphorylated derivatives of phosphatidylinositol are important as a participant in essential metabolic processes in animals. However,due to its low abundance in cells and tissues, it is difficult to identify the composition of phosphoinositides.
Recent advances in mass spectrometric techniques,combined with established separation methods, have allowed the rapid and sensitive detection and quantification of a variety of lipid species including phosphoinositides.
In this mini review, we briefly introduce progress in profiling of cellular phosphoinositides using mass spectrometry. We also summarize current progress of matrices development for the analysis of cellular phospholipids using matrix-assisted laser desorption/ionization mass spectrometry. The phosphoinositides profiling and phospholipids imaging will help us to understand how they function in a biological system and will provide a powerful tool for elucidating the mechanism of diseases such as diabetes, cancer and neurodegenerative diseases. The investigation of cellular phospholipids including phosphoinositides using electrospray ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry will suggest new insights on human diseases,and on clinical application through drug development of lipid related diseases.
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참고문헌 (20)
참고문헌 신청
Astigarraga E / 2008 / Profiling and Imaging of Lipids on Brain and Liver Tissue by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Using 2-Mercaptobenzothiazol
Berry GT / 2004 / Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain / Mol Genet Metab 82 : 87 ~ 92
Bouschen W / 2007 / Artifacts of MALDI sample preparation investigated by high-resolution scanning microprobe matrix-assisted laser desorption/ionization (SMALDI) imaging mas
Cascante M / 2002 / Metabolic control analysis in drug discovery and disease / Nat Biotechnol 20 : 243 ~ 249
Chen Y / 2008 / Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse
Berry GT / 2004 / Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain / Mol Genet Metab 82 : 87 ~ 92
Bouschen W / 2007 / Artifacts of MALDI sample preparation investigated by high-resolution scanning microprobe matrix-assisted laser desorption/ionization (SMALDI) imaging mas
Cascante M / 2002 / Metabolic control analysis in drug discovery and disease / Nat Biotechnol 20 : 243 ~ 249
Chen Y / 2008 / Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse
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