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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 297 - 306 (10page)
이용수
초록· 키워드
오류제보하기
Increased expression of a number of proinflammatory
genes, including IL-8, is associated with inflammatory
conditions such as asthma. Glucocorticoid receptor
(GR)β, one of the GR isoforms, has been suggested to
be upregulated in asthma associated with glucocorticoid
insensitivity and to work as a dominant negative
inhibitor of wild type GRα. However, recent data suggest
that GRβ is not a dominant negative inhibitor of
GRα in the transrepressive process and has its own
functional role. We investigated the functional role of
GRβ expression in the suppressive effect of glucocorticoids
on tumor necrosis factor (TNF)-α-induced
IL-8 release in an airway epithelial cell line. GRβ expression
was induced by treatment of epithelial cells
with either dexamethasone or TNF-α. GRβ was able to
inhibit glucocorticoid-induced transcriptional activation
mediated by binding to glucocorticoid response
elements (GREs). The suppressive effect of dexamethasone
on TNF-α-induced IL-8 transcription was
not affected by GRβ overexpression, rather GRβ had
its own weak suppressive activity on TNF-α-induced
IL-8 expression. Overall histone deacetylase activity
and histone acetyltransferase activity were not
changed by GRβ overexpression, but TNF-α-induced
histone H4 acetylation at the IL-8 promoter was decreased
with GRβ overexpression. This study suggests
that GRβ overexpression does not affect glucocorticoid-
induced suppression of IL-8 expression in
airway epithelial cells and GRβ induces its own histone
deacetylase activity around IL-8 promoter site.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Barnes PJ / 2001 / Molecular mechanisms of corticosteroids in allergic diseases / Allergy 56 : 928 ~ 936
Barnes PJ / 2005 / Histone acetylation and deacetylation: importance in inflammatory lung diseases / Eur Respir J 25 : 552 ~ 563
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 : 143 ~ 178
Caelles C / 1997 / Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway / Genes Dev 11 : 3351 ~ 3364
Drouin J / 1993 / Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene / EMBO J 12 : 145 ~ 156
Barnes PJ / 2005 / Histone acetylation and deacetylation: importance in inflammatory lung diseases / Eur Respir J 25 : 552 ~ 563
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 : 143 ~ 178
Caelles C / 1997 / Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway / Genes Dev 11 : 3351 ~ 3364
Drouin J / 1993 / Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene / EMBO J 12 : 145 ~ 156
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