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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 334 - 340 (7page)
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The effects of glucagon and epinephrine on gluconeogenesis
in young (4 month) and old (24 month)
Fisher 344 rat hepatocytes were compared. In contrast
to glucagon, which had a similar effect on gluconeogenesis
in both young and old cells, epinephrine
caused a smaller increase in gluconeogenesis in old
rat hepatocytes than in young hepatocytes. β2 adrenergic
receptor (β2-AR) expression slightly decreased
in aged rat liver, and there were differences
between young and old hepatocytes in their patterns
of G protein coupled receptor kinases, which are involved
in the activation of β2-AR receptor signal
desensitization. The major isoform of the kinase
changed from GRK2 to GRK3 and the expression of
β-arrestin, which is recruited by the phosphorylated
β2-AR for internalization and degradation, increased
in aged rat liver. GRK3 overexpression also decreased
the glucose output from young rat hepatocytes.
We conclude that an age-associated reduction
in epinephrine-induced gluconeogenesis occurs
through the epinephrine receptor desensitizing
system.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Benovic JL / 1991 / Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family / J Biol Chem 266 : 149
Burgess SC / 2004 / Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase / J Biol Chem 279 : 48941 ~ 48949
Dax EM / 1981 / Mechanism of the age-related decrease of epinephrine-stimulated lipolysis in isolated rat adipocytes: beta-adrenergic receptor binding, adenylate cyclase acti
Dax EM / 1987 / Beta-adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging / Endocrinology 120 : 1534 ~ 1541
Dobson JG Jr / 2003 / Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling / Physiol Genomics 15 : 142 ~ 147
Burgess SC / 2004 / Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase / J Biol Chem 279 : 48941 ~ 48949
Dax EM / 1981 / Mechanism of the age-related decrease of epinephrine-stimulated lipolysis in isolated rat adipocytes: beta-adrenergic receptor binding, adenylate cyclase acti
Dax EM / 1987 / Beta-adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging / Endocrinology 120 : 1534 ~ 1541
Dobson JG Jr / 2003 / Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling / Physiol Genomics 15 : 142 ~ 147
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